用于评估抗糖尿病药物的急性和慢性动物模型。
Acute and chronic animal models for the evaluation of anti-diabetic agents.
机构信息
Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Post Box: 38, Hisar-125001, India.
出版信息
Cardiovasc Diabetol. 2012 Jan 19;11:9. doi: 10.1186/1475-2840-11-9.
Abstract
Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic (immunological) manipulations. Most of the experiments in diabetes are carried out in rodents, although some studies are still performed in larger animals. The present review highlights the various methods of inducing diabetes in experimental animals in order to test the newer drugs for their anti-diabetic potential.
摘要
糖尿病是一种潜在的病态疾病，在全球范围内患病率很高，因此是一个主要的医学关注点。在动物模型中诱导糖尿病的实验对于我们对其发病机制的各个方面的知识和理解的推进以及最终找到新的治疗方法和治愈方法至关重要。一般来说，实验性糖尿病可以通过多种方法在实验动物中诱导，包括：化学、手术和遗传（免疫）操作。大多数糖尿病实验都是在啮齿动物中进行的，尽管仍有一些研究在较大的动物中进行。本综述强调了在实验动物中诱导糖尿病的各种方法，以便测试新型药物的抗糖尿病潜力。
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