Zhang Wen-Feng, Yang Yan, Su Xin, Xu Da-Yan, Yan Yu-Li, Gao Qiao, Duan Ming-Hua
Changchun University of Chinese Medicine, Changchun Jingyue Street, Boshuo Road 1035, Changchun, Jilin, China.
Saudi J Gastroenterol. 2016 Nov;22(6):448-455. doi: 10.4103/1319-3767.195552.
BACKGROUND/AIMS: Deoxyschizandrin as one of the most important component of Schisandra chinensis (Turcz.) Baill plays an immunomodulatory role in a variety of diseases, yet its role in ulcerative colitis remains to be elucidated. We aimed to investigate the role of deoxyschizandrin in DSS-induced ulcerative colitis in mice.
In the present study, an inflammation model of cells was constructed to confirm the anti-inflammatory effect of deoxyschizandrin. Then a mouse model with Dextran sulfate sodium sulfate (DSS)-induced ulcerative colitis was constructed, and the effects of deoxyschizandrin on mouse colon inflammation, apoptosis, and CD4 T lymphocyte infiltration in ulcerative colitis were examined.
Deoxyschizandrin could improve the symptoms of ulcerative colitis, determined by hematoxylin-eosin (HE) staining and histopathological scores. Moreover, deoxyschizandrin reduced the levels of inflammatory cytokines, suppressed CD4 T cell infiltration, and effectively inhibited apoptosis in the colon of DSS-induced ulcerative colitis mice.
In summary, deoxyschizandrin can effectively rescue the symptoms of DSS-induced ulcerative colitis in mice by inhibiting inflammation. T cell infiltration and apoptosis in the colon, suggesting that deoxyschizandrin could be a potential drug in treating ulcerative colitis.
背景/目的：五味子醇甲作为五味子的最重要成分之一，在多种疾病中发挥免疫调节作用，但其在溃疡性结肠炎中的作用仍有待阐明。我们旨在研究五味子醇甲在葡聚糖硫酸钠（DSS）诱导的小鼠溃疡性结肠炎中的作用。
在本研究中，构建细胞炎症模型以证实五味子醇甲的抗炎作用。然后构建DSS诱导的溃疡性结肠炎小鼠模型，并检测五味子醇甲对溃疡性结肠炎小鼠结肠炎症、细胞凋亡和CD4 T淋巴细胞浸润的影响。
苏木精-伊红（HE）染色和组织病理学评分显示，五味子醇甲可改善溃疡性结肠炎症状。此外，五味子醇甲降低了炎症细胞因子水平，抑制了CD4 T细胞浸润，并有效抑制了DSS诱导的溃疡性结肠炎小鼠结肠中的细胞凋亡。
综上所述，五味子醇甲可通过抑制炎症、T细胞浸润和结肠细胞凋亡有效缓解DSS诱导的小鼠溃疡性结肠炎症状，表明五味子醇甲可能是治疗溃疡性结肠炎的潜在药物。
