自噬功能障碍是剥脱性青光眼的关键吗？
Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?
机构信息
Departments of Ophthalmology.
Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.
出版信息
J Glaucoma. 2018 Mar;27(3):197-201. doi: 10.1097/IJG.0000000000000606.
Abstract
In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.
摘要
在这份简短的报告中，我们回顾了之前针对剥脱性青光眼的蛋白质和细胞来源的鉴定工作，并描述了我们最近在手术时从剥脱综合征青光眼患者的眼外囊组织中获得的成纤维细胞中的自噬功能障碍方面的发现，并讨论了这些发现对理解疾病的细胞来源的潜在意义。
相似文献
1
Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?自噬功能障碍是剥脱性青光眼的关键吗？
J Glaucoma. 2018 Mar;27(3):197-201. doi: 10.1097/IJG.0000000000000606.
2
Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients.剥脱性青光眼患者Tenon成纤维细胞中的自噬与线粒体功能障碍
PLoS One. 2016 Jul 8;11(7):e0157404. doi: 10.1371/journal.pone.0157404. eCollection 2016.
3
Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats.基质金属蛋白酶和细胞因子在大鼠青光眼滤过或植入手术后巩膜成纤维细胞瘢痕形成中的表达。
Cell Biochem Funct. 2013 Aug;31(6):482-8. doi: 10.1002/cbf.2923. Epub 2012 Oct 19.
4
Exfoliation syndrome angle characteristics: a lack of correlation with amount of disc damage.剥脱综合征房角特征：与盘状损害程度无关。
Br J Ophthalmol. 2004 Aug;88(8):1002-3. doi: 10.1136/bjo.2003.031732.
5
Current concepts in the pathogenesis and management of exfoliation syndrome and exfoliative glaucoma.
Compr Ophthalmol Update. 2006 May-Jun;7(3):131-41.
6
Comments on: Current concepts in the pathogenesis and management of exfoliation syndrome and exfoliative glaucoma.
Compr Ophthalmol Update. 2006 May-Jun;7(3):143-4.
7
Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients.剥脱综合征和剥脱性青光眼患者房水中胃饥饿素的水平。
Jpn J Ophthalmol. 2014 Jul;58(4):348-52. doi: 10.1007/s10384-014-0322-8. Epub 2014 May 8.
8
An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y-27632, a Rho kinase inhibitor.一项关于人眼Tenon 纤维细胞介导的瘢痕形成的体外研究：Rho 激酶抑制剂 Y-27632 的作用。
Cell Biochem Funct. 2019 Mar;37(2):113-124. doi: 10.1002/cbf.3382. Epub 2019 Feb 18.
9
The Expression and Role of Hypoxia-induced Factor-1α in Human Tenon's Capsule Fibroblasts under Hypoxia.缺氧条件下人眼Tenon囊成纤维细胞中缺氧诱导因子-1α的表达及作用
Curr Eye Res. 2021 Mar;46(3):417-425. doi: 10.1080/02713683.2020.1805470. Epub 2020 Sep 16.
10
Increased aqueous autotaxin and lysophosphatidic acid levels are potential prognostic factors after trabeculectomy in different types of glaucoma.眼滤过术后不同类型青光眼房水中的自分泌酶和溶血磷脂酸水平升高是潜在的预后因素。
Sci Rep. 2018 Jul 27;8(1):11304. doi: 10.1038/s41598-018-29649-3.
引用本文的文献
1
Evaluation of the effect of autophagy on pseudoexfoliation syndrome.自噬对假性剥脱综合征影响的评估
J Int Med Res. 2025 Sep;53(9):3000605241306612. doi: 10.1177/03000605241306612. Epub 2025 Sep 9.
2
Protein misfolding and mitochondrial dysfunction in glaucoma.青光眼患者的蛋白质错误折叠与线粒体功能障碍
Front Cell Dev Biol. 2025 Apr 25;13:1595121. doi: 10.3389/fcell.2025.1595121. eCollection 2025.
3
Mitochondrial and microtubule defects in Exfoliation Glaucoma.剥脱性青光眼中的线粒体和微管缺陷
Free Radic Biol Med. 2025 Jun;233:226-239. doi: 10.1016/j.freeradbiomed.2025.03.046. Epub 2025 Apr 1.
4
A Feedback Loop between TGF-β1 and Mediated by miR-122-5p Regulates Fibrosis and EMT in Human Trabecular Meshwork Cells.由miR-122-5p介导的TGF-β1与之间的反馈回路调节人小梁网细胞中的纤维化和上皮-间质转化。
Curr Issues Mol Biol. 2023 Mar 13;45(3):2381-2392. doi: 10.3390/cimb45030154.
5
Alternate Causes for Pathogenesis of Exfoliation Glaucoma, a Multifactorial Elastotic Disorder: A Literature Review.剥脱性青光眼发病机制的其他原因：一种多因素弹性组织变性疾病的文献综述
Curr Issues Mol Biol. 2022 Mar 1;44(3):1191-1202. doi: 10.3390/cimb44030078.
6
Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis.地塞米松通过加速小梁细胞中 Ulk-1 复合物的周转来下调自噬：对类固醇诱导性青光眼发病机制的见解。
Int J Mol Sci. 2021 May 31;22(11):5891. doi: 10.3390/ijms22115891.
7
Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway.川芎嗪通过 PI3K/Akt/mTOR 信号通路诱导缺血/再灌注损伤的视网膜神经节细胞存活、抑制细胞凋亡和自噬。
Bioengineered. 2021 Dec;12(1):507-515. doi: 10.1080/21655979.2021.1880060.
8
LOXL1 folding in exfoliation glaucoma.LOXL1 在剥脱性青光眼的折叠中。
Adv Protein Chem Struct Biol. 2019;118:273-288. doi: 10.1016/bs.apcsb.2019.09.005. Epub 2019 Oct 21.
9
Exfoliation Syndrome: A Disease of Autophagy and LOXL1 Proteopathy.剥脱综合征：自噬和 LOXL1 蛋白病。
J Glaucoma. 2018 Jul;27 Suppl 1(Suppl 1):S44-S53. doi: 10.1097/IJG.0000000000000919.
本文引用的文献
1
Autophagy in the eye: Development, degeneration, and aging.眼内自噬：发育、变性和衰老。
Prog Retin Eye Res. 2016 Nov;55:206-245. doi: 10.1016/j.preteyeres.2016.08.001. Epub 2016 Aug 23.
2
Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients.剥脱性青光眼患者Tenon成纤维细胞中的自噬与线粒体功能障碍
PLoS One. 2016 Jul 8;11(7):e0157404. doi: 10.1371/journal.pone.0157404. eCollection 2016.
3
Autophagy and mechanotransduction in outflow pathway cells.房水流出通路细胞中的自噬与机械转导
Exp Eye Res. 2017 May;158:146-153. doi: 10.1016/j.exer.2016.06.021. Epub 2016 Jun 29.
4
Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells.错误折叠蛋白的非常规分泌促进哺乳动物细胞对蛋白酶体功能障碍的适应。
Nat Cell Biol. 2016 Jul;18(7):765-76. doi: 10.1038/ncb3372. Epub 2016 Jun 13.
5
Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography.使用频域光学相干断层扫描技术评估假性剥脱综合征非青光眼患者的筛板和脉络膜
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1293-300. doi: 10.1167/iovs.15-18312.
6
Systemic Associations of Exfoliation Syndrome.剥脱综合征的全身关联
Asia Pac J Ophthalmol (Phila). 2016 Jan-Feb;5(1):45-50. doi: 10.1097/APO.0000000000000187.
7
Ethnicity-Based Differences in the Association of LOXL1 Polymorphisms with Pseudoexfoliation/Pseudoexfoliative Glaucoma: A Meta-Analysis.赖氨酰氧化酶样蛋白1（LOXL1）基因多态性与假性剥脱综合征/假性剥脱性青光眼相关性的种族差异：一项荟萃分析
Ann Hum Genet. 2015 Nov;79(6):431-50. doi: 10.1111/ahg.12128. Epub 2015 Sep 24.
8
Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.与剥脱综合征相关的基因变异和细胞应激源可调节LOXL1基因座内一个长链非编码RNA的启动子活性。
Hum Mol Genet. 2015 Nov 15;24(22):6552-63. doi: 10.1093/hmg/ddv347. Epub 2015 Aug 25.
9
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.一个定位到CACNA1A基因的常见变异与剥脱综合征易感性相关。
Nat Genet. 2015 Apr;47(4):387-92. doi: 10.1038/ng.3226. Epub 2015 Feb 23.
10
Update on pseudoexfoliation syndrome pathogenesis and associations with intraocular pressure, glaucoma and systemic diseases.假性剥脱综合征的发病机制及其与眼压、青光眼和全身性疾病的关联的最新进展
Curr Opin Ophthalmol. 2015 Mar;26(2):82-9. doi: 10.1097/ICU.0000000000000132.
Zotero 插件