Departments of Ophthalmology.
Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.
J Glaucoma. 2018 Mar;27(3):197-201. doi: 10.1097/IJG.0000000000000606.
In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.
在这份简短的报告中，我们回顾了之前针对剥脱性青光眼的蛋白质和细胞来源的鉴定工作，并描述了我们最近在手术时从剥脱综合征青光眼患者的眼外囊组织中获得的成纤维细胞中的自噬功能障碍方面的发现，并讨论了这些发现对理解疾病的细胞来源的潜在意义。
