Department of Drug Design, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Org Lett. 2016 Dec 16;18(24):6396-6399. doi: 10.1021/acs.orglett.6b03293. Epub 2016 Dec 1.
The Passerini multicomponent reaction (P-3CR) toward the one-step synthesis of α-aminoxy-amide, by employing for the first time a N-hydroxamic acid component, has been reported. The sonication-accelerated, catalyst-free, simple, fast, and highly efficient Passerini reaction is used for the synthesis of diverse α-aminoxy-amides. The reaction is compatible with a vast range of aldehydes, isocyanides, and N-hydroxamic acids such as N-hydroxysuccinimides and phthalimides. The generated Passerini products can be easily converted into several follow-up products.
首次采用 N-羟肟酸作为一种新的反应组分，报道了 Passerini 多组分反应（P-3CR）一步法合成α-氨氧基酰胺。超声加速、无催化剂、简便、快速、高效的 Passerini 反应用于合成各种α-氨氧基酰胺。该反应对各种醛、异氰化物和 N-羟肟酸（如琥珀酰亚胺和邻苯二甲酰亚胺）具有广泛的适用性。生成的 Passerini 产物可以很容易地转化为几种后续产物。
