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1
Intestinal Microbiome, , and Medical Nutrition Therapy.肠道微生物群与医学营养治疗
Integr Med (Encinitas). 2016 Oct;15(5):14-16.
2
A critical review of the relationship between dietary components, the gut microbe , and human health.膳食成分、肠道微生物与人类健康之间关系的批判性综述。
Crit Rev Food Sci Nutr. 2020;60(13):2265-2276. doi: 10.1080/10408398.2019.1632789. Epub 2019 Jul 1.
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Dietary Factors and Modulation of Bacteria Strains of and : A Systematic Review.饮食因素与 和 细菌菌株的调节:系统评价。
Nutrients. 2019 Jul 11;11(7):1565. doi: 10.3390/nu11071565.
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Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas.对 39 株阿克曼氏菌黏蛋白亚种的基因组测序揭示了其种群结构、基因组和功能多样性,以及在哺乳动物肠道微生物群中的全球分布。
BMC Genomics. 2017 Oct 18;18(1):800. doi: 10.1186/s12864-017-4195-3.
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Akkermansia muciniphila and Helicobacter typhlonius modulate intestinal tumor development in mice.嗜黏蛋白阿克曼氏菌和盲肠幽门螺杆菌可调节小鼠肠道肿瘤的发展。
Carcinogenesis. 2015 Nov;36(11):1388-96. doi: 10.1093/carcin/bgv120. Epub 2015 Aug 29.
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Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.黏蛋白阿克曼氏菌与肥胖人群饮食干预期间代谢健康的改善:与肠道微生物丰富度和生态的关系。
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Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B Production by Intestinal Symbionts.微生物代谢网络位于黏液层,可导致肠道共生菌产生不依赖饮食的丁酸和维生素 B。
mBio. 2017 Sep 19;8(5):e00770-17. doi: 10.1128/mBio.00770-17.
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Action and function of Akkermansia muciniphila in microbiome ecology, health and disease.阿克曼氏菌在微生物组生态学、健康和疾病中的作用和功能。
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NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model.NOD2 缺乏促进肠道 CD4+T 淋巴细胞失衡、代谢炎症,并加重小鼠 2 型糖尿病。
Front Immunol. 2020 Jul 7;11:1265. doi: 10.3389/fimmu.2020.01265. eCollection 2020.
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Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis.羟氯喹对类风湿关节炎相关动脉粥样硬化的保护作用。
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Getting to Know the Gut Microbial Diversity of Metropolitan Buenos Aires Inhabitants.了解布宜诺斯艾利斯大都市居民的肠道微生物多样性。
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Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model.白细胞介素-17/白细胞介素-17 受体轴引发肠道中性粒细胞迁移,抑制高脂肪饮食诱导的代谢综合征模型中的肠道菌群失调和脂多糖易位。
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Prebiotic Effect of Fructooligosaccharides from on Alzheimer's Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis.低聚果糖通过靶向微生物群-肠-脑轴对啮齿动物模型阿尔茨海默病的益生元作用
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本文引用的文献

1
Complex Relationships Between Food, Diet, and the Microbiome.食物、饮食与微生物群之间的复杂关系。
Gastroenterol Clin North Am. 2016 Jun;45(2):253-65. doi: 10.1016/j.gtc.2016.02.004.
2
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.肝细胞髓样分化因子88影响胆汁酸、肠道微生物群和代谢组,有助于调节葡萄糖和脂质代谢。
Gut. 2017 Apr;66(4):620-632. doi: 10.1136/gutjnl-2015-310904. Epub 2016 May 5.
3
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice.阿克曼氏菌(Akkermansia muciniphila)通过预防载脂蛋白 E 基因敲除(Apoe-/-)小鼠的代谢性内毒素血症诱导的炎症来预防动脉粥样硬化。
Circulation. 2016 Jun 14;133(24):2434-46. doi: 10.1161/CIRCULATIONAHA.115.019645. Epub 2016 Apr 25.
4
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.基于人群的宏基因组学分析揭示了肠道微生物组组成和多样性的标志物。
Science. 2016 Apr 29;352(6285):565-9. doi: 10.1126/science.aad3369. Epub 2016 Apr 28.
5
Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn's Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets.克罗恩病患者中,改变可发酵寡糖、双糖、单糖和多元醇(FODMAP)摄入量时,益生元对肠道微生物群具有持续影响:一项关于明确饮食的随机对照交叉试验
Clin Transl Gastroenterol. 2016 Apr 14;7(4):e164. doi: 10.1038/ctg.2016.22.
6
Microbiome: Eating for trillions.微生物群:为万亿微生物而饮食。
Nature. 2016 Apr 21;532(7599):316-7. doi: 10.1038/nature17887. Epub 2016 Apr 13.
7
Altered gastrointestinal microbiota in irritable bowel syndrome and its modification by diet: probiotics, prebiotics and the low FODMAP diet.肠易激综合征的胃肠道微生物群改变及其饮食调节:益生菌、益生元和低 FODMAP 饮食。
Proc Nutr Soc. 2016 Aug;75(3):306-18. doi: 10.1017/S0029665116000021. Epub 2016 Feb 24.
8
Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?用膳食多酚激活阿克曼氏菌:对抗代谢综合征的新武器?
Gut Microbes. 2016;7(2):146-53. doi: 10.1080/19490976.2016.1142036.
9
Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.肥胖和2型糖尿病肠道微生物生物标志物的亚临床检测
Genome Med. 2016 Feb 17;8(1):17. doi: 10.1186/s13073-016-0271-6.
10
Akkermansia muciniphila and its role in regulating host functions.嗜黏蛋白阿克曼氏菌及其在调节宿主功能中的作用。
Microb Pathog. 2017 May;106:171-181. doi: 10.1016/j.micpath.2016.02.005. Epub 2016 Feb 11.

肠道微生物群与医学营养治疗

Intestinal Microbiome, , and Medical Nutrition Therapy.

作者信息

Bland Jeffrey

机构信息

, , is the president and founder of the Personalized Lifestyle Medicine Institute in Seattle, Washington. He has been an internationally recognized leader in nutrition medicine for more than 25 years. Dr Bland is the cofounder of the Institute for Functional Medicine (IFM) and is chairman emeritus of IFM's Board of Directors. He is the author of the 2014 book The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life.

出版信息

Integr Med (Encinitas). 2016 Oct;15(5):14-16.

PMID:27980489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5145007/
Abstract

The gastrointestinal microbiome has become a topic of great interest in medicine in recent years. Genomic sequencing can now be done at a fraction of the cost of a few years ago, and this has allowed for the development and compilation of an extensive amount of data related to the species diversity of the human gastrointestinal microbiome.1 Studies have demonstrated that the intestinal microbiome is sensitive to the composition of the diet.2 It is also recognized that the composition of the microbiome can be altered rapidly in response to dietary changes, stress, chemical exposure, and exercise.3 Both the expanded understanding of the composition of the human microbiome and the ability to measure it through genomic analysis of the stool have resulted in clinicians frequently wanting to know what actionable conclusions can be taken away from an analysis of the gastrointestinal microbiome.

摘要

近年来,胃肠道微生物群已成为医学领域备受关注的话题。现在进行基因组测序的成本仅为几年前的一小部分,这使得与人类胃肠道微生物群物种多样性相关的大量数据得以开发和汇编。1 研究表明,肠道微生物群对饮食组成敏感。2 人们还认识到,微生物群的组成会因饮食变化、压力、化学物质暴露和运动而迅速改变。3 对人类微生物群组成的更深入了解以及通过粪便基因组分析来测量它的能力,使得临床医生常常想知道从胃肠道微生物群分析中可以得出哪些可采取行动的结论。