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中国浙江省西部氢氟酸烧伤:一项为期10年的流行病学研究。

Hydrofluoric acid burns in the western Zhejiang Province of China: a 10-year epidemiological study.

作者信息

Zhang Yuanhai, Zhang Jianfen, Jiang Xinhua, Ni Liangfang, Ye Chunjiang, Han Chunmao, Sharma Komal, Wang Xingang

机构信息

Department of Burns & Plastic Surgery, Zhejiang Quhua Hospital, Quzhou, 324004 China.

Department of Burns & Wound Care Center, Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, 310009 China.

出版信息

J Occup Med Toxicol. 2016 Dec 7;11:55. doi: 10.1186/s12995-016-0144-3. eCollection 2016.

Abstract

BACKGROUND

Chemical burns caused by hydrofluoric acid (HF) frequently occur in the Western Zhejiang Province. This study aimed to investigate the epidemiological characteristics of HF burns within this region.

METHODS

A 10-year retrospective analysis was conducted using data from all inpatients with HF burns. These patients were treated at the Department of Burns and Plastic Surgery at our hospital between January 2004 and December 2013. Information obtained for each patient included sex, age, occupation, burn location, burn cause, and the hazard category of the chemical which caused the burn. Data regarding wound site and size, accompanying injuries, serum electrolyte levels, operations, length of hospital stay, and mortality were also assessed.

RESULTS

A total of 201 patients (189 males, 12 females; average age: 38.33 ± 10.57 years) were admitted due to HF burns. Over the 10-year period, the morbidity of HF burns in the past 10 years showed a gradual increase, which paralleled the development of local fluoride industries. Most HF injuries were work related and distributed in working-age patients. Aqueous HF solutions, especially highly concentrated ones, were the most common chemical cause of HF burns. Moreover, inappropriate operation, machine problems, and inadequate protection were identified as the leading causes of HF burns in the workplace. The burn area was <5% of TBSA in more than 90% of patients, and the most common burn sites were the head, neck, and upper extremities. Approximately 17% of patients underwent surgical operation. Accompanying injuries should be detected and treated correctly in a timely manner. Lastly, electrolyte imbalances, such as hypocalcaemia, hypomagnesaemia, and hypokalaemia, occurred frequently in patients with HF exposure; however, hyperkalaemia was not encountered in this study.

CONCLUSION

Based on the epidemiological results for HF burns in this region, the related enterprises and local authorities should be encouraged to upgrade management policies and to provide necessary occupational hazard education and safety training for high-risk occupations within high-risk working populations. Furthermore, the enhancement of hazardous chemicals management is also needed. Finally, for patients with HF exposure, early and correct pre-hospital triage, treatment and consequent in-hospital treatment and procedures should also be improved.

摘要

背景

氢氟酸(HF)所致化学烧伤在浙江省西部频繁发生。本研究旨在调查该地区氢氟酸烧伤的流行病学特征。

方法

对所有氢氟酸烧伤住院患者的数据进行了为期10年的回顾性分析。这些患者于2004年1月至2013年12月在我院烧伤整形科接受治疗。收集的每位患者信息包括性别、年龄、职业、烧伤部位、烧伤原因以及致伤化学物质的危险类别。还评估了伤口部位和大小、伴随损伤、血清电解质水平、手术情况、住院时间和死亡率等数据。

结果

共有201例因氢氟酸烧伤入院患者(男性189例,女性12例;平均年龄:38.33±10.57岁)。在这10年期间,过去10年氢氟酸烧伤的发病率呈逐渐上升趋势,这与当地氟化工行业的发展情况相平行。大多数氢氟酸损伤与工作相关,且分布于工作年龄患者。氢氟酸水溶液,尤其是高浓度的,是氢氟酸烧伤最常见的化学致伤原因。此外,操作不当、机器问题和防护不足被确定为工作场所氢氟酸烧伤的主要原因。超过90%的患者烧伤面积小于总体表面积的5%,最常见的烧伤部位是头、颈和上肢。约17%的患者接受了手术治疗。应及时正确地检测和治疗伴随损伤。最后,接触氢氟酸的患者经常出现电解质失衡,如低钙血症、低镁血症和低钾血症;然而,本研究中未遇到高钾血症。

结论

基于该地区氢氟酸烧伤的流行病学结果,应鼓励相关企业和地方当局完善管理政策,为高危工作人群中的高危职业提供必要的职业危害教育和安全培训。此外,还需要加强危险化学品管理。最后,对于接触氢氟酸的患者,还应改进早期和正确的院前分诊、治疗以及随后的院内治疗和程序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed7/5142164/6eb6e5e808ba/12995_2016_144_Fig1_HTML.jpg

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