Psychiatric Center Copenhagen, Rigshospitalet, University of Copenhgaen, Blegdamsvej 9, DK- 2100 Copenhagen, Denmark.
Psychiatric Center Copenhagen, Rigshospitalet, University of Copenhgaen, Blegdamsvej 9, DK- 2100 Copenhagen, Denmark.
Neurosci Biobehav Rev. 2017 Feb;73:68-80. doi: 10.1016/j.neubiorev.2016.12.007. Epub 2016 Dec 13.
Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV changes from mania/depression to euthymia; and HRV changes following interventions.
A systematic review and meta-analysis reported according to the PRISMA guidelines was conducted. MEDLINE, Embase, PsycINFO, The Cochrane Library and Scopus were searched. A total of 15 articles comprising 2534 individuals were included.
HRV was reduced in BD compared to HC (g=-1.77, 95% CI: -2.46; -1.09, P<0.001, 10 comparisons, n=1581). More recent publication year, larger study and higher study quality were associated with a smaller difference in HRV. Large between-study heterogeneity, low study quality, and lack of consideration of confounding factors in individual studies were observed.
This first meta-analysis of HRV in BD suggests that HRV is reduced in BD compared to HC. Heterogeneity and methodological issues limit the evidence. Future studies employing strict methodology are warranted.
与健康个体（HC）相比，双相情感障碍（BD）患者的心率变异性（HRV）降低。本荟萃分析研究了：与 HC、重性抑郁障碍或精神分裂症相比，BD 患者的 HRV 差异；情感状态之间的 HRV 差异；从躁狂/抑郁到轻躁狂的 HRV 变化；以及干预后的 HRV 变化。
根据 PRISMA 指南进行了系统评价和荟萃分析。检索了 MEDLINE、Embase、PsycINFO、The Cochrane Library 和 Scopus。共纳入了 15 篇文章，共 2534 人。
与 HC 相比，BD 患者的 HRV 降低（g=-1.77，95%CI：-2.46；-1.09，P<0.001，10 项比较，n=1581）。较新的发表年份、较大的研究和较高的研究质量与 HRV 差异较小相关。存在较大的研究间异质性、研究质量较低，以及个别研究中未考虑混杂因素。
这是对 BD 中 HRV 的首次荟萃分析，表明与 HC 相比，BD 患者的 HRV 降低。异质性和方法学问题限制了证据。需要采用严格方法学的未来研究。
