Department of Mechanical & Industrial Engineering, Ryerson University, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Department of Mechanical & Industrial Engineering, Ryerson University, Toronto, Ontario, Canada.
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:401-411. doi: 10.1016/j.msec.2016.10.024. Epub 2016 Oct 18.
With over a million median sternotomy surgeries performed worldwide every year, sternal wound complications have posed a serious risk to the affected patients. A rigid therapeutic sternal fixation device has therefore become a necessity. In this work, the incorporation of up to 0.5mol% of tantalum pentoxide (TaO), in exchange for zinc oxide (ZnO), into the SiO-ZnO-CaO-SrO-PO glass system is presented. The effect of Ta incorporation on the physical, chemical and biological properties of the glass polyalkenoate cements (GPCs) prepared from them have been presented in this manuscript. The data obtained have confirmed that TaO incorporation into the reference glass system results in increased working times, radiopacity, ion solubility, and long-term mechanical stability. The formulated glass systems have also shown clear antibacterial and antifungal activity against both Gram-negative (Escherichia coli) and Gram-positive prokaryotes (Staphylococcus aureus and Streptococcus epidermidis), as well as eukaryotes (Fusarium solani). Cytotoxicity testing showed that Ta incorporation results in no toxicity effect and may simulate osseo-integration when tested in animal models. These new metallic-containing biomaterial adhesives have been developed for sternal fixation and repair. As a permanent implant, the formulated adhesives can be used in conjunction with sternal cable ties to offer optimal fixation for patients and reduce post-operative complications such as bacterial infection and pain from micro-motion.
每年全球有超过一百万例正中胸骨切开术，胸骨伤口并发症对受影响的患者构成了严重威胁。因此，刚性治疗性胸骨固定装置成为必需品。在这项工作中，将多达 0.5mol%的五氧化二钽（TaO），替代氧化锌（ZnO），掺入 SiO-ZnO-CaO-SrO-PO 玻璃系统中。本文介绍了 Ta 掺入对由此制备的玻璃聚烯酸酯水泥（GPC）的物理、化学和生物学性质的影响。获得的数据证实，TaO 掺入参考玻璃系统会导致工作时间、射线不透明度、离子溶解度和长期机械稳定性增加。所制定的玻璃系统还对革兰氏阴性（大肠杆菌）和革兰氏阳性原核生物（金黄色葡萄球菌和表皮葡萄球菌）以及真核生物（茄病镰刀菌）表现出明显的抗菌和抗真菌活性。细胞毒性测试表明，Ta 掺入不会产生毒性作用，并且在动物模型中测试时可能模拟骨整合。这些新的含金属生物材料胶粘剂已开发用于胸骨固定和修复。作为永久性植入物，所配制的胶粘剂可与胸骨索带一起使用，为患者提供最佳固定，并减少术后并发症，如细菌感染和微动引起的疼痛。
