载磺胺嘧啶银壳聚糖复合海绵的构建及其作为潜在伤口敷料的研究。
Construction of silver sulfadiazine loaded chitosan composite sponges as potential wound dressings.
机构信息
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China; Jiangsu Key Lab of Biomass Based Green Fuels and Chemicals, Nanjing 210037, PR China.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
出版信息
Carbohydr Polym. 2017 Feb 10;157:1963-1970. doi: 10.1016/j.carbpol.2016.11.087. Epub 2016 Nov 30.
Chitosan/silver sulfadiazine (CS/AgSD) composite sponges were prepared by incorporating AgSD particles into CS matrix in order to develop novel biomaterials for wound healing. The co-existence of CS and AgSD in the composite sponges was confirmed by SEM, FTIR and XRD spectra, respectively. The porosity and swelling properties of the fabricated CS/AgSD composite sponges were examined and the results indicated that they had high porosity and excellent swelling behaviors. Antibacterial property of the CS/AgSD composite sponges was also performed against E. coli, C. albicans, S. aureus and B. subtilis, respectively. The results showed that they possessed broad spectrum of antibacterial activity. The cytotoxicity of the prepared composite sponges was performed by MTT viability assay and fluorescence staining method on HEK293 cell lines. The cell viability results indicated that the designed sponges had no significant cytotoxicity. The results of this study demonstrated that the CS/AgSD composite sponges have potential application in antimicrobial wound dressing materials.
壳聚糖/磺胺嘧啶银（CS/AgSD）复合海绵通过将磺胺嘧啶银颗粒掺入壳聚糖基质中制备而成，旨在开发用于伤口愈合的新型生物材料。通过 SEM、FTIR 和 XRD 图谱分别证实了 CS 和 AgSD 在复合海绵中的共存。对制备的 CS/AgSD 复合海绵的孔隙率和溶胀性能进行了研究，结果表明它们具有高孔隙率和优异的溶胀性能。还分别对 CS/AgSD 复合海绵对大肠杆菌、白色念珠菌、金黄色葡萄球菌和枯草芽孢杆菌的抗菌性能进行了测试。结果表明它们具有广谱的抗菌活性。通过 MTT 活力测定法和荧光染色法对 HEK293 细胞系进行了制备复合海绵的细胞毒性测试。细胞活力测试结果表明设计的海绵没有明显的细胞毒性。该研究结果表明，CS/AgSD 复合海绵在抗菌伤口敷料材料方面具有潜在的应用前景。
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