内皮细胞 miRNAs 作为心脏代谢疾病中的细胞信使。

Endothelial miRNAs as Cellular Messengers in Cardiometabolic Diseases.

机构信息

Laboratory of Molecular Angiogenesis, GIGA-R, University of Liège, Liège, Belgium; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada.

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada.

出版信息

Trends Endocrinol Metab. 2017 Mar;28(3):237-246. doi: 10.1016/j.tem.2016.11.009. Epub 2016 Dec 15.

DOI:10.1016/j.tem.2016.11.009

PMID:27989505

Abstract

Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the underlying mechanisms will advance the development of diagnostic and therapeutic approaches. A prominent feature of cardiometabolic diseases is endothelial dysfunction. Endothelial cell (EC) homeostasis and response to pathological stimuli are controlled by gene regulatory networks in which miRNAs play a critical role. Recently, miRNAs have been implicated as cell-cell messengers that can influence cellular function. This review investigates the known and potential roles for miRNA-based cell-cell communication in the control of cardiovascular health and explores the value of identifying miRNA biomarkers and developing therapeutics that harness or antagonize miRNA-based communication.

摘要

代谢综合征是一组危险因素的聚集，增加了发生严重心血管代谢并发症的易感性，包括 2 型糖尿病（T2D）和心肌梗死。了解潜在的机制将促进诊断和治疗方法的发展。心血管代谢疾病的一个突出特征是内皮功能障碍。内皮细胞（EC）的稳态和对病理刺激的反应受基因调控网络控制，miRNA 在其中发挥关键作用。最近，miRNA 被认为是细胞间信使，可以影响细胞功能。本综述研究了 miRNA 为基础的细胞间通讯在控制心血管健康中的已知和潜在作用，并探讨了鉴定 miRNA 生物标志物和开发利用或拮抗 miRNA 为基础的通讯的治疗方法的价值。