内皮细胞稳态和血管疾病中的 microRNAs。
MicroRNAs in endothelial cell homeostasis and vascular disease.
机构信息
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Curr Opin Hematol. 2018 May;25(3):227-236. doi: 10.1097/MOH.0000000000000424.
PURPOSE OF REVIEW
Since the first discovery of microRNAs (miRNAs) in 1993, the involvement of miRNAs in different aspects of vascular disease has emerged as an important research field. In this review, we summarize the fundamental roles of miRNAs in controlling endothelial cell functions and their implication with several aspects of vascular dysfunction.
RECENT FINDINGS
MiRNAs have been found to be critical modulators of endothelial homeostasis. The dysregulation of miRNAs has been linked to endothelial dysfunction and the development and progression of vascular disease which and open new opportunities of using miRNAs as potential therapeutic targets for vascular disease.
SUMMARY
Further determination of miRNA regulatory circuits and defining miRNAs-specific target genes remains key to future miRNA-based therapeutic applications toward vascular disease prevention. Many new and unanticipated roles of miRNAs in the control of endothelial functions will assist clinicians and researchers in developing potential therapeutic applications.
目的综述
自 1993 年首次发现 microRNAs（miRNAs）以来，miRNAs 参与血管疾病的不同方面已成为一个重要的研究领域。在这篇综述中，我们总结了 miRNAs 在控制内皮细胞功能中的基本作用及其与血管功能障碍几个方面的关系。
最近的发现
miRNAs 被发现是内皮细胞稳态的关键调节因子。miRNAs 的失调与内皮功能障碍以及血管疾病的发生和发展有关，并为使用 miRNAs 作为血管疾病潜在治疗靶点提供了新的机会。
总结
进一步确定 miRNA 调控回路并确定 miRNA 特异性靶基因仍然是未来 miRNA 治疗血管疾病应用的关键。miRNAs 在控制内皮功能中的许多新的和意外的作用将帮助临床医生和研究人员开发潜在的治疗应用。
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