Moalla Rekik Dorsaf, Ben Khedir Sameh, Ksouda Moalla Kamilia, Kammoun Naziha Grati, Rebai Tarek, Sahnoun Zouheir
Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia.
Evid Based Complement Alternat Med. 2016;2016:7965689. doi: 10.1155/2016/7965689. Epub 2016 Nov 20.
. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. . Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and -carotene discoloration. Uniform wound excision was induced on rats dorsum randomly divided into five groups: groups treated with "®" and tested oils and untreated one. The posthealing biopsies were histologically assessed. . Wound biopsies treated with oils showed the best tissue regeneration compared to control groups. Groups treated with our oils and "" had higher wound contraction percentage. Polyunsaturated fatty acids in oils act as inflammatory mediators increasing neovascularization, extracellular remodeling, migration, and cell differentiation. Wound healing effect was attributed to antibacterial and antioxidant synergy. . According to findings, oils showed better activity in wound healing compared to "" due to a phytoconstituents synergy. However, clinical trials on humans are necessary to confirm efficacy on human pathology.
药用植物一直以来都被证明是一种强大的医疗保健药物。因此，具有药理特性的葡萄籽、芝麻和胡芦巴提取油被作为伤口治疗药物进行研究。本研究评估了我们的油对大鼠伤口愈合的潜力。对油进行了植物化学分析，包括：质量值、多酚、叶绿素、胡萝卜素和脂肪酸。进行了抗菌活性测试。评估了抗氧化活性：对DPPH自由基的清除作用、还原能力和β-胡萝卜素褪色情况。在随机分为五组的大鼠背部诱导进行均匀的伤口切除：用“®”和受试油处理的组以及未处理的组。对愈合后的活检组织进行了组织学评估。与对照组相比，用油处理的伤口活检组织显示出最佳的组织再生。用我们的油和“”处理的组伤口收缩百分比更高。油中的多不饱和脂肪酸作为炎症介质，可增加新血管形成、细胞外重塑、迁移和细胞分化。伤口愈合效果归因于抗菌和抗氧化协同作用。根据研究结果，由于植物成分的协同作用，与“”相比，油在伤口愈合方面表现出更好的活性。然而，需要对人类进行临床试验以确认对人类病理的疗效。
