Landaas Elisabeth Toverud, Aarsland Tore Ivar Malmei, Ulvik Arve, Halmøy Anne, Ueland Per Magne, Haavik Jan
, MD, PhD, K.G Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.
, Stud. med., K.G Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.
BJPsych Open. 2016 Dec 13;2(6):377-384. doi: 10.1192/bjpo.bp.116.003491. eCollection 2016 Nov.
Micronutrients containing vitamins are reported to reduce symptom levels in persons with attention-deficit hyperactivity disorder (ADHD), but data on vitamin levels in ADHD are sparse.
To examine the relationship between vitamin concentrations, ADHD diagnosis and psychiatric symptoms in young adult ADHD patients and controls.
Eight vitamins and the nicotine metabolite cotinine were analysed in serum samples from 133 ADHD patients and 131 controls aged between 18 and 40, who also reported ADHD symptoms and comorbid conditions.
Lower concentrations of vitamins B2, B6 and B9 were associated with the ADHD diagnosis, and B2 and B6 also with symptom severity. Smokers had lower levels of vitamins B2 and B9.
ADHD patients were overrepresented in the group with low levels of some vitamins, possibly indicative of inadequate dietary intake of these micronutrients in a subgroup of patients. It is important to identify these patients in dietary intervention trials of ADHD.
J.H. has received lecture honoraria as part of continuing medical education programmes sponsored by Novartis, Eli Lilly and Company, and Janssen-Cilag.
© The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.
据报道，含维生素的微量营养素可降低注意力缺陷多动障碍（ADHD）患者的症状水平，但关于ADHD患者维生素水平的数据却很稀少。
研究青年ADHD患者及对照组中维生素浓度、ADHD诊断与精神症状之间的关系。
对133例ADHD患者和131例年龄在18至40岁之间的对照组的血清样本进行了8种维生素及尼古丁代谢产物可替宁的分析，这些患者和对照组还报告了ADHD症状及共病情况。
维生素B2、B6和B9浓度较低与ADHD诊断相关，B2和B6还与症状严重程度相关。吸烟者的维生素B2和B9水平较低。
在某些维生素水平较低的人群中，ADHD患者的比例过高，这可能表明部分患者这些微量营养素的饮食摄入量不足。在ADHD的饮食干预试验中识别出这些患者很重要。
J.H.作为诺华、礼来公司和杨森-西拉格赞助的继续医学教育项目的一部分，已获得讲课酬金。
©皇家精神科医学院2016年。本文是一篇开放获取文章，根据知识共享非商业性、无衍生作品（CC BY-NC-ND）许可条款分发。
