Piskunowicz Maciej, Swieton Dominik, Rybczynska Dorota, Szarmach Arkadiusz, Szurowska Edyta, Pruijm Menno
Department of Radiology, Medical University of Gdansk, Gdańsk, Poland.
Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland.
Biomed Res Int. 2016;2016:1764692. doi: 10.1155/2016/1764692. Epub 2016 Nov 20.
The aim of this study is to describe premature microbubbles destruction with contrast-enhanced voiding urosonography (ce-VUS) in children using 2nd-generation ultrasound contrast agents (UCA) and to hypothesize about the reason. 141 children (61 females and 80 males) were included in the study, with mean age of 3.3 years (range 4 weeks-16.0 years), who underwent ce-VUS examination between 2011 and 2014. Premature destruction of the microbubbles in the urinary bladder during ce-VUS was observed in 11 children (7.8%). In all these cases the voiding phase of ce-VUS examination could not be performed because of destroyed UCA microbubbles. This was noted in anxious, crying infants and children with restricted voiding. The premature destruction of ultrasound contrast agent during ce-VUS is an underreported, important limitation of ce-VUS, which prevents evaluation of the voiding phase and the establishment of vesicoureteric reflux (VUR). This was particularly noted in crying infants and children.
本研究的目的是描述使用第二代超声造影剂（UCA）的儿童对比增强排尿超声检查（ce-VUS）中微泡的过早破坏情况，并对其原因进行推测。141名儿童（61名女性和80名男性）纳入本研究，平均年龄3.3岁（范围4周 - 16.0岁），于2011年至2014年间接受ce-VUS检查。在ce-VUS检查期间，11名儿童（7.8%）观察到膀胱内微泡过早破坏。在所有这些病例中，由于UCA微泡被破坏，ce-VUS检查的排尿期无法进行。这在焦虑、哭闹的婴儿以及排尿受限的儿童中被注意到。ce-VUS期间超声造影剂的过早破坏是ce-VUS一个报道不足的重要局限性，它妨碍了对排尿期的评估以及膀胱输尿管反流（VUR）的判定。这在哭闹的婴儿和儿童中尤为明显。
