Department for Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute (BPI), University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Department of Cranio-Maxillo-Facial Surgery, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Adv Healthc Mater. 2017 Feb;6(3). doi: 10.1002/adhm.201600902. Epub 2016 Dec 19.
Bone glues often suffer from low adhesion to bone under wet conditions. This study aims to improve wet adhesiveness of a bone glue based on a photocurable poly(ethylene glycol) dimethacrylate matrix through in situ interpenetrating network formation by addition of six-armed isocyanate functional star-shaped prepolymers (NCO-sP(EO-stat-PO)). Biodegradable ceramic fillers are added to adjust the paste workability. The 3-point bending strength of the bone glues is in the range of 3.5-5.5 MPa and not significantly affected by the addition of NCO-sP(EO-stat-PO). Storage in phosphate buffered saline (PBS) decreases the bending strength of all formulations to approximately 1 MPa but the adhesion to cortical bone increases from 0.15-0.2 to 0.3-0.5 MPa after adding 20-40 wt% NCO-sP(EO-stat-PO) to the matrix. Bone glues without the NCO-sP(EO-stat-PO) additive lose their adhesiveness to bone after aging in PBS for 7 days, whereas modified glues maintain a shear strength of 0.18-0.25 MPa demonstrating the efficacy of the approach. Scanning electron microscopy and energy-dispersive X-ray spectroscopy investigations of the fracture surfaces prove a high amount of residual adhesive on the bone surface indicating that adhesion to the bone under wet conditions is stronger than cohesion.
骨胶在潮湿条件下通常与骨的粘合强度较低。本研究旨在通过添加六臂异氰酸酯官能星形预聚物（NCO-sP(EO-stat-PO)）来改善基于光固化聚乙二醇二甲基丙烯酸酯基质的骨胶的湿粘性。可生物降解的陶瓷填料被添加以调整糊剂的工作性能。骨胶的 3 点弯曲强度在 3.5-5.5 MPa 范围内，添加 NCO-sP(EO-stat-PO) 后不会显著影响。在磷酸盐缓冲盐水（PBS）中储存会使所有配方的弯曲强度降低到约 1 MPa，但在基质中添加 20-40wt%的 NCO-sP(EO-stat-PO)后，与皮质骨的粘合强度从 0.15-0.2 增加到 0.3-0.5 MPa。没有添加 NCO-sP(EO-stat-PO)的骨胶在 PBS 中老化 7 天后会失去对骨的粘性，而改性胶在保持 0.18-0.25 MPa 的剪切强度，证明了这种方法的有效性。对断裂表面的扫描电子显微镜和能量色散 X 射线能谱研究表明，在骨表面上有大量残留的粘性物质，这表明在潮湿条件下对骨的粘合强度强于内聚强度。
