Brückner Theresa, Meininger Markus, Groll Jürgen, Kübler Alexander C, Gbureck Uwe
Department for Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany.
Department of Oral & Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany.
Materials (Basel). 2019 Nov 21;12(23):3819. doi: 10.3390/ma12233819.
Mineral bone cements were actually not developed for their application as bone-bonding agents, but as bone void fillers. In particular, calcium phosphate cements (CPC) are considered to be unsuitable for that application, particularly under moist conditions. Here, we showed the ex vivo ability of different magnesium phosphate cements (MPC) to adhere on bovine cortical bone substrates. The cements were obtained from a mixture of farringtonite (Mg(PO)) with different amounts of phytic acid (CHOP, inositol hexaphosphate, IP6), whereas cement setting occurred by a chelation reaction between Mg ions and IP6. We were able to show that cements with 25% IP6 and a powder-to-liquid ratio (PLR) of 2.0 g/mL resulted in shear strengths of 0.81 ± 0.12 MPa on bone even after 7 d storage in aqueous conditions. The samples showed a mixed adhesive-cohesive failure with cement residues on the bone surface as indicated by scanning electron microscopy and energy-dispersive X-ray analysis. The presented material demonstrated appropriate bonding characteristics, which could enable a broadening of the mineral bone cements' application field to bone adhesives.
矿物骨水泥实际上并非因其作为骨黏合剂的应用而开发，而是作为骨缺损填充剂。特别是磷酸钙水泥（CPC）被认为不适用于该应用，尤其是在潮湿条件下。在此，我们展示了不同磷酸镁水泥（MPC）在体外对牛皮质骨基质的黏附能力。这些水泥由不同量植酸（C₆H₁₈O₂₄P₆，肌醇六磷酸，IP6）的镁橄榄石（Mg₂SiO₄）混合物制得，而水泥固化是通过Mg离子与IP6之间的螯合反应发生的。我们能够表明，含25% IP6且粉液比（PLR）为2.0 g/mL的水泥，即使在水性条件下储存7天后，在骨上的剪切强度仍为0.81±0.12 MPa。扫描电子显微镜和能量色散X射线分析表明，样品呈现混合的黏附-内聚破坏，骨表面有水泥残渣。所展示的材料表现出合适的黏结特性，这可能使矿物骨水泥的应用领域扩展到骨黏合剂。
