Heppell L M, Sissons J W, Banks S M
AFRC Institute for Grassland and Animal Production, Reading, Berkshire.
Res Vet Sci. 1989 Sep;47(2):257-62.
The immune response stimulated by dietary protein was studied in preruminant calves and piglets. Calves receiving dietary soya developed high serum titres of soya-specific IgG which did not decline with prolonged feeding. IgG1 and IgG2 subclasses showed a parallel rise although IgG1 predominated. Levels of antibody evoked by a combination of oral and parenteral sensitisation with soya protein were significantly greater than by parenteral sensitisation alone. These results suggest that the calves failed to develop oral tolerance. Passively acquired maternal soya-specific antibody did not influence the response to oral or parenteral sensitisation with soya. By contrast, piglets weaned onto a soya-containing diet became hyporesponsive to injection with soya protein. Thus, calves and piglets appear to differ in their ability to control adverse immune responses to dietary antigens. This could influence the severity of gastrointestinal disorders associated with early weaning diets.
在反刍前犊牛和仔猪中研究了膳食蛋白质刺激的免疫反应。接受含大豆膳食的犊牛产生了高血清滴度的大豆特异性IgG，且随着长期喂食该滴度并未下降。IgG1和IgG2亚类呈现平行上升，尽管IgG1占主导。通过口服和肠胃外联合用大豆蛋白致敏所诱发的抗体水平显著高于仅通过肠胃外致敏所诱发的抗体水平。这些结果表明犊牛未能形成口服耐受。被动获得的母体大豆特异性抗体不影响对大豆进行口服或肠胃外致敏的反应。相比之下，断奶后食用含大豆日粮的仔猪对注射大豆蛋白反应低下。因此，犊牛和仔猪在控制对膳食抗原的不良免疫反应的能力上似乎存在差异。这可能会影响与早期断奶日粮相关的胃肠道疾病的严重程度。
