Bailey M, Miller B G, Telemo E, Stokes C R, Bourne F J
Department of Veterinary Medicine, University of Bristol, Langford, UK.
Int Arch Allergy Immunol. 1994;103(2):183-7. doi: 10.1159/000236625.
The weaning of piglets onto soya proteins at 3 weeks old normally results in an active response to the fed protein, as determined by the appearance of serum IgG antisoya antibody. This system thus allows the effects of manipulation on the response to a fed protein to be studied. In animals previously given 1 g of soya protein at birth, the magnitude of the antibody response to soya fed at 3 weeks was decreased, although similar amounts of the fed protein could be detected in serum. In addition, the relative affinity of the dominant interaction between antigen and antibody was reduced in these piglets by almost an order of magnitude. By comparison, the ability of piglets given soya at birth to respond to injected soya was not significantly reduced. These results indicate that the regulation of responses to fed and systemic antigens is largely separate. Very early oral exposure to antigen may affect the ability of neonatal animals to mount immune responses to, specifically, fed proteins while leaving the response to systemic antigen largely intact.
通常情况下，仔猪在3周龄时断奶并开始食用大豆蛋白，会引发对所喂蛋白质的活跃反应，这可通过血清IgG抗大豆抗体的出现来确定。因此，该系统使得对所喂蛋白质反应的调控效果得以研究。在出生时曾喂食1克大豆蛋白的动物中，尽管血清中能检测到等量的所喂蛋白质，但3周龄时对所喂大豆的抗体反应强度有所降低。此外，这些仔猪体内抗原与抗体之间主要相互作用的相对亲和力降低了近一个数量级。相比之下，出生时喂食大豆的仔猪对注射大豆的反应能力并未显著降低。这些结果表明，对所喂抗原和全身性抗原的反应调控在很大程度上是分开的。极早期口服接触抗原可能会影响新生动物对所喂蛋白质产生免疫反应的能力，而对全身性抗原的反应基本保持完好。
