Barratt M E, Strachan P J, Porter P
Clin Exp Immunol. 1978 Feb;31(2):305-12.
Serum antibody responses to ingested aqueous alcohol-extracted soya proteins were studied in thirty-six pre-ruminant calves. Characterization of this antibody showed it to be predominantly a complement-fixing IgG1 preciptin. No evidence of tolerance was seen; previously sensitized calves responded to reintroduction of a soya diet with marked increases in antibody levels. The soya antigen was shown to be resistant to proteolysis and, to a lesser degree, to the microbial action of rumen fluid. Biopsy studies showed that the feeding of soya protein resulted in morphological disturbances to the villi and lamina propria of the intestine. Physiological studies by Thirty-Vella loop perfusion in the pig showed that soya protein solutions resulted in significant inhibition of flow rates. The effect was only observed after previous sensitization with the soya antigen. This study shows the necessity of applying immunological criteria to the quality control of soya bean processing in order to ensure that the sensitizing agent is eliminated and the nutritional qualities of soya protein concentrates are optimized.
对36头反刍前犊牛摄入水相酒精提取大豆蛋白后的血清抗体反应进行了研究。对该抗体的特性分析表明，它主要是一种补体结合IgG1沉淀素。未观察到耐受性的证据；先前致敏的犊牛再次引入大豆日粮后，抗体水平显著升高。大豆抗原显示出对蛋白水解有抗性，对瘤胃液的微生物作用也有一定抗性。活检研究表明，饲喂大豆蛋白会导致肠道绒毛和固有层的形态紊乱。通过对猪进行Thirty-Vella肠袢灌注的生理学研究表明，大豆蛋白溶液会导致流速显著降低。这种效应只有在先前用大豆抗原致敏后才会观察到。本研究表明，有必要将免疫学标准应用于大豆加工的质量控制，以确保消除致敏剂并优化大豆浓缩蛋白的营养品质。
