Bailey M, Miller B G, Telemo E, Stokes C R, Bourne F J
Department of Veterinary Medicine, University of Bristol, Langford, UK.
Int Arch Allergy Immunol. 1993;101(3):266-71. doi: 10.1159/000236456.
Young piglets weaned onto soya diets frequently develop diarrhoea which may have a dietary and/or immunological component. Piglets abruptly weaned onto soya at 3 weeks of age developed levels of serum IgG anti-soya antibodies almost comparable to those induced by injection with soya protein in adjuvant at 7 weeks. In the piglets primed by feeding, no significant further increase in antibody occurred after subsequent systemic injection. In contrast, secondary responses were observed in age-matched animals, previously primed by injection, and primary responses were obtained in previously naive piglets. The results demonstrate the development of specific unresponsiveness to soya proteins in neonates fed soya, despite the occurrence of an initial vigorous immune response to the fed protein.
刚断奶转喂大豆日粮的幼龄仔猪常发生腹泻，腹泻可能有饮食和/或免疫方面的因素。3周龄时突然断奶转喂大豆的仔猪，其血清抗大豆IgG抗体水平几乎与7周龄时注射佐剂中的大豆蛋白所诱导的水平相当。在通过喂食致敏的仔猪中，随后进行全身注射后抗体未出现显著进一步增加。相比之下，在先前通过注射致敏的年龄匹配动物中观察到了二次反应，而在先前未接触过抗原的仔猪中获得了初次反应。结果表明，尽管对所喂蛋白质最初会产生强烈的免疫反应，但喂食大豆的新生仔猪会出现对大豆蛋白的特异性无反应性。
