Lindquist B, Edward S, Torell P, Krasse B
Department of Cariology, University of Gothenburg Sweden.
Scand J Dent Res. 1989 Aug;97(4):330-7. doi: 10.1111/j.1600-0722.1989.tb01620.x.
The caries preventive effect of topical application of fluoride varnish (Duraphat), ferric-aluminum-fluoride solution (FeAlF) and chlorhexidine gel was compared in 2-yr clinical study. Children with more than 10(6) mutans steptococci per ml saliva were selected and a total of 189 13-yr-old children participated in the study. The children in the fluoride groups were treated every third month with either Duraphat or FeAlF-solution. In the chlorhexidine group children with more than 2.5 x 10(5) mutans streptococci per ml of saliva were treated every third month. The mean number of new decayed and filled tooth surfaces was 3.06 in the chlorhexidine group, 5.88 in the Duraphat group, 5.33 in the FeAlF group, and 6.34 in the control group. Thus supervised antimicrobial treatment can significantly reduce the incidence of dental (caries) in children with high numbers of mutans streptococci.
在一项为期两年的临床研究中，对局部应用氟化物漆（Duraphat）、铁铝氟化物溶液（FeAlF）和氯己定凝胶的防龋效果进行了比较。选择每毫升唾液中变形链球菌超过10⁶的儿童，共有189名13岁儿童参与了该研究。氟化物组的儿童每三个月接受一次Duraphat或FeAlF溶液治疗。在氯己定组中，每毫升唾液中变形链球菌超过2.5×10⁵的儿童每三个月接受一次治疗。氯己定组新出现的龋坏和充填牙面的平均数量为3.06，Duraphat组为5.88，FeAlF组为5.33，对照组为6.34。因此，监督下的抗菌治疗可以显著降低变形链球菌数量较多的儿童患龋齿的发生率。
