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本文引用的文献

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PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION.妊娠期牙周病。II. 口腔卫生与牙周状况的相关性
Acta Odontol Scand. 1964 Feb;22:121-35. doi: 10.3109/00016356408993968.
2
PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY.妊娠期牙周病。I. 患病率与严重程度。
Acta Odontol Scand. 1963 Dec;21:533-51. doi: 10.3109/00016356309011240.
3
Antiplaque biocides and bacterial resistance: a review.抗菌斑杀菌剂与细菌耐药性：综述
J Clin Periodontol. 2002 Nov;29(11):965-74. doi: 10.1034/j.1600-051x.2002.291101.x.
4
Assessment of cytogenetic damage in lymphocytes and in exfoliated nasal cells of dental laboratory technicians exposed to chromium, cobalt, and nickel.对接触铬、钴和镍的牙科实验室技术人员淋巴细胞和脱落鼻细胞的细胞遗传学损伤评估。
Mutat Res. 2002 Nov 26;521(1-2):47-56. doi: 10.1016/s1383-5718(02)00215-2.
5
Monitoring of buccal epithelial cells by alkaline comet assay (single cell gel electrophoresis technique) in cytogenetic evaluation of chlorhexidine.在洗必泰的细胞遗传学评估中，通过碱性彗星试验（单细胞凝胶电泳技术）监测颊上皮细胞。
Clin Oral Investig. 2002 Sep;6(3):150-4. doi: 10.1007/s00784-002-0168-1. Epub 2002 Jul 25.
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Effectiveness of chlorhexidine-thymol varnish for caries reduction in permanent first molars of 6-7-year-old children: 24-month clinical trial.
Community Dent Oral Epidemiol. 2002 Oct;30(5):363-8. doi: 10.1034/j.1600-0528.2002.00061.x.
7
The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque regrowth.与精油漱口水和氯己定漱口水相比，聚六亚甲基双胍漱口水对细菌计数和4天菌斑再生长的影响。
J Clin Periodontol. 2002 May;29(5):392-9. doi: 10.1034/j.1600-051x.2002.290503.x.
8
In vitro cytotoxicity of chlorhexidine gluconate, benzydamine-HCl and povidone iodine mouthrinses on human gingival fibroblasts.葡萄糖酸氯己定、盐酸苄达明和聚维酮碘漱口水对人牙龈成纤维细胞的体外细胞毒性
SADJ. 2001 Oct;56(10):455-60.
9
Effect of different chlorhexidine formulations in mouthrinses on de novo plaque formation.含漱液中不同洗必泰制剂对新发牙菌斑形成的影响。
J Clin Periodontol. 2001 Dec;28(12):1127-36. doi: 10.1034/j.1600-051x.2001.281207.x.
10
Mechanisms underlying chlorhexidine-induced cytotoxicity.洗必泰诱导细胞毒性的潜在机制。
Toxicol In Vitro. 2001 Aug-Oct;15(4-5):271-6. doi: 10.1016/s0887-2333(01)00020-0.

通过微核试验检测漱口水对上皮细胞的细胞毒性。

Cytotoxicity of mouthrinses on epithelial cells by micronucleus test.

作者信息

Erdemir Ebru Olgun, Sengün Abdulkadir, Ulker Mustafa

机构信息

Assistant Professor, Kirikkale University, Faculty of Dentistry, Department of Periodontology, Kirikkale, Turkey.

出版信息

Eur J Dent. 2007 Apr;1(2):80-5.

PMID:19212481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2609950/
Abstract

OBJECTIVES

To determine the cytotoxicity of three commercial mouthrinses Klorhex, Andorex and Tanflex on buccal epithelial cells using micronucleus (MN) test.

MATERIALS AND METHODS

28 patients with aged 16-24 undergone three mouthrinses' application were analyzed before and after one week exposure. Physiologic saline was used for the control group. The MN incidence was scored in the buccal epithelial of each participants. The difference in pre- and post-treatment after one week incidence of MN and plaque (PI) and gingival indices (GI) was compared by non-parametric statistical tests.

RESULTS

The micronuclei incidence increased in Klorhex, Tanflex and Andorex groups after exposure to mouth rinses (P<.05). But when compared with the control group, there was not any difference between Andorex and control group (P>.05). In the other study groups, MN incidence was significantly increased after 7 days treatment (P<.05). GI scores of all groups were decreased significantly (P<.05). PI scores were decreased only in the Klorhex group (P<.05).

CONCLUSIONS

Our primary findings support the presence of possible cytotoxic effects of the mouthrinses on gingival epithelial cells.

摘要

目的

使用微核（MN）试验确定三种市售漱口水Klorhex、Andorex和Tanflex对颊上皮细胞的细胞毒性。

材料与方法

对28名年龄在16 - 24岁之间使用过三种漱口水的患者在暴露一周前后进行分析。生理盐水用于对照组。对每位参与者颊上皮细胞中的微核发生率进行评分。通过非参数统计检验比较一周后微核发生率、菌斑指数（PI）和牙龈指数（GI）治疗前后的差异。

结果

使用漱口水后，Klorhex、Tanflex和Andorex组的微核发生率增加（P<0.05）。但与对照组相比，Andorex组与对照组之间无差异（P>0.05）。在其他研究组中，治疗7天后微核发生率显著增加（P<0.05）。所有组的牙龈指数评分均显著降低（P<0.05）。菌斑指数评分仅在Klorhex组降低（P<0.05）。

结论

我们的主要研究结果支持漱口水可能对牙龈上皮细胞产生细胞毒性作用。