高通量膜血液透析患者中β2微球蛋白与炎症和血脂异常的关联
Association of Beta-2 Microglobulin with Inflammation and Dislipidemia in High-Flux Membrane Hemodialysis Patients.
作者信息
Topçiu-Shufta Valdete, Miftari Ramë, Haxhibeqiri Valdete, Haxhibeqiri Shpend
机构信息
Clinic of Medical Biochemistry, University Clinical Center, Pristina, Republic of Kosova; Faculty of Medicine, University of Prishtina, Republic of Kosova.
Faculty of Medicine, University of Prishtina, Republic of Kosova.
出版信息
Med Arch. 2016 Oct;70(5):348-350. doi: 10.5455/medarh.2016.70.348-350. Epub 2016 Oct 25.
BACKGROUND
Higher than expected cardiovascular mortality in hemodialysis patients, has been attributed to dyslipidemia as well as inflammation. Beta2-Microglobulin (β2M) is an independent predictor of outcome for hemodialysis patients and a representative substance of middle molecules.
RESULTS
In 40 patients in high-flux membrane hemodialysis, we found negative correlation of β2M with high density lipoprotein (r=-0.73, p<0.001) and albumin (r= -0.53, p<0.001) and positive correlation with triglycerides (r=0.69, p<0.001), parathyroid hormone (r=0.58, p < 0.05) and phosphorus (r= 0.53, p<0.001). There was no correlation of β2M with C- reactive protein (CRP) and interleukin-6 (IL-6). During the follow-up period of three years, 6 out of 40 patients have died from cardiovascular events.
CONCLUSION
In high-flux membrane hemodialysis patients, we observed a significant relationship of β2M with dyslipidemia and mineral bone disorders, but there was no correlation with inflammation.
背景
血液透析患者心血管死亡率高于预期，这归因于血脂异常以及炎症。β2微球蛋白（β2M）是血液透析患者预后的独立预测因子，也是中分子物质的代表性物质。
结果
在40例高通量膜血液透析患者中，我们发现β2M与高密度脂蛋白呈负相关（r = -0.73，p < 0.001）以及与白蛋白呈负相关（r = -0.53，p < 0.001），与甘油三酯呈正相关（r = 0.69，p < 0.001）、与甲状旁腺激素呈正相关（r = 0.58，p < 0.05）以及与磷呈正相关（r = 0.53，p < 0.001）。β2M与C反应蛋白（CRP）和白细胞介素-6（IL-6）无相关性。在三年的随访期内，40例患者中有6例死于心血管事件。
结论
在高通量膜血液透析患者中，我们观察到β2M与血脂异常和矿物质骨代谢紊乱存在显著关系，但与炎症无相关性。
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