慢性肾脏病中的继发性甲状旁腺功能亢进与靶器官
Secondary hyperparathyroidism and target organs in chronic kidney disease.
作者信息
Nikodimopoulou M, Liakos S
机构信息
1 Propedeutic Medical Department, AHEPA Hospital, Aristotles University of Thessaloniki,Greece.
出版信息
Hippokratia. 2011 Jan;15(Suppl 1):33-8.
Abstract
Secondary hyperparathyroidism (SHPT) is a common disorder in patients with chronic kidney disease (CKD) and is characterized by excessive serum parathyroid hormone (PTH) levels, parathyroid hyperplasia and an imbalance in calcium and phosphorus metabolism. Secondary hyperparathyroidism develops early in the course of CKD and becomes more prominent as kidney function declines.PTH is a major uremic toxin and may be responsible for long-term consequences that include renal osteodystrophy, severe vascular calcifications, alterations in cardiovascular structure and function, immune dysfunction, and anemia. These adverse effects may contribute to an increased risk of cardiovascular morbidity and mortality among end-stage renal failure patients.
摘要
继发性甲状旁腺功能亢进（SHPT）是慢性肾脏病（CKD）患者的常见病症，其特征为血清甲状旁腺激素（PTH）水平过高、甲状旁腺增生以及钙磷代谢失衡。继发性甲状旁腺功能亢进在CKD病程早期就会出现，并随着肾功能下降而愈发显著。PTH是一种主要的尿毒症毒素，可能导致包括肾性骨营养不良、严重血管钙化、心血管结构和功能改变、免疫功能障碍及贫血等长期后果。这些不良反应可能会增加终末期肾衰竭患者心血管发病和死亡的风险。
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本文引用的文献
1
Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals.活性维生素D可减轻膳食钠在 Dahl 盐敏感型动物中诱发的左心室异常。
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16810-5. doi: 10.1073/pnas.0611202104. Epub 2007 Oct 17.
2
The relationship between renal function and cardiac structure, function, and prognosis after myocardial infarction: the VALIANT Echo Study.心肌梗死后肾功能与心脏结构、功能及预后的关系：VALIANT 超声心动图研究
J Am Coll Cardiol. 2007 Sep 25;50(13):1238-45. doi: 10.1016/j.jacc.2007.06.018. Epub 2007 Sep 10.
3
Surgical approach and clinical outcome of a deforming brown tumor at the maxilla in a patient with secondary hyperparathyroidism due to chronic renal failure.
Arq Bras Endocrinol Metabol. 2006 Oct;50(5):963-7. doi: 10.1590/s0004-27302006000500021.
4
Diagnosis of renal osteodystrophy.肾性骨营养不良的诊断
Eur J Clin Invest. 2006 Aug;36 Suppl 2:13-22. doi: 10.1111/j.1365-2362.2006.01666.x.
5
The role of advanced glycation end products in the development of atherosclerosis.晚期糖基化终末产物在动脉粥样硬化发展中的作用。
Curr Diab Rep. 2004 Feb;4(1):31-6. doi: 10.1007/s11892-004-0008-6.
6
The rugger jersey spine sign.橄榄球运动员衫脊柱征。
Radiology. 2004 Feb;230(2):491-2. doi: 10.1148/radiol.2302020388.
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