Déciga-Campos Myrna, Navarrete-Vázquez Gabriel, López-Muñoz Francisco Javier, Librowski Tadeusz, Sánchez-Recillas Amanda, Yañez-Pérez Victor, Ortiz-Andrade Rolffy
Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México.
Facultad de Farmacia de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
Data Brief. 2016 Jul 16;8:1007-1012. doi: 10.1016/j.dib.2016.07.019. eCollection 2016 Sep.
This text presents complementary data corresponding to pharmacological and toxicological characterization of -(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled "Pharmacological profile of -(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analog of lidocaine" Déciga-Campos M., Navarrete-Vázquez G., López-Muñoz F.J., Librowski T., Sánchez-Recillas A., Yañez-Pérez V., Ortiz-Andrade R. (2016) [1]. Toxicity was predicted through the ACD/ToxSuite software and evaluated using brine shrimp larvae ( L.) and mice. Also, we used the micronucleus assay to determine genotoxicity. We used the platform admetSAR to predict absorption properties of LIA and lidocaine.
本文呈现了与-(2,6-二氯苯基)-2-(4-甲基-1-哌啶基)乙酰胺（LIA）化合物的药理学和毒理学特性相关的补充数据。这些数据支持了我们题为“-(2,6-二氯苯基)-2-(4-甲基-1-哌啶基)乙酰胺的药理学概况，一种利多卡因的新型类似物”的研究文章，作者为Déciga-Campos M.、Navarrete-Vázquez G.、López-Muñoz F.J.、Librowski T.、Sánchez-Recillas A.、Yañez-Pérez V.、Ortiz-Andrade R.（2016年）[1]。通过ACD/ToxSuite软件预测毒性，并使用卤虫幼虫（L.）和小鼠进行评估。此外，我们使用微核试验来确定遗传毒性。我们使用admetSAR平台预测LIA和利多卡因的吸收特性。
