Déciga-Campos Myrna, Rivero-Cruz Isabel, Arriaga-Alba Myriam, Castañeda-Corral Gabriela, Angeles-López Guadalupe E, Navarrete Andrés, Mata Rachel
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico.
J Ethnopharmacol. 2007 Mar 21;110(2):334-42. doi: 10.1016/j.jep.2006.10.001. Epub 2006 Oct 13.
The present work was undertaken to determine safety parameters of selected Mexican medicinal plants chosen on the basis of their frequency of medicinal use and commercial importance. The medicinal herbs included Amphipteryngium adstringens, Hintonia standleyana, Hintonia latiflora, Piper sanctum, Haemathoxylon brasiletto, Iostephane heterophylla, Valeriana procera, Arracacia tolucensis, Brickellia veronicaefolia, Scaphyglottis livida, Exostema caribaeum, Hippocratea excelsa, Ligusticum porteri, Poliomintha longiflora and Gnaphalium sp. In the acute toxicity studies in mice performed according to the Lorke procedure, Exostema caribaeum, Hippocratea excelsa, Ligusticum porteri and Poliomintha longiflora were the most toxic with LD(50) values between 1085 and 2mg/kg. The Ames test revealed that Gnaphalium sp. and Valeriana procera extracts induced mutations of S. typhimurium TA98 with or without the S9 microsomal fraction, and TA100 in the presence of the enzymatic fraction, respectively. The tincture of Valeriana procera, however, was non-mutagenic. Finally, in the Artemia salina lethality test Brickellia veronicaefolia, Arracacia tolucensis, Poliomintha longiflora and Piper sanctum caused significant mortality of the crustacean larvae with LC(50) in the range of 37-227 microg/mL.
本研究旨在确定根据药用频率和商业重要性挑选出的墨西哥药用植物的安全参数。这些药草包括收敛双翅果、斯坦德利希托尼亚木、阔叶希托尼亚木、圣胡椒、巴西苏木、异叶艾氏菊、高氏缬草、托卢卡阿辣卡西亚、紫茎泽兰叶千里光、青紫舌唇兰、加勒比外蕊木、卓越希波克拉底木、波特川芎、长花薄荷和鼠麴草属植物。在按照洛尔科程序对小鼠进行的急性毒性研究中，加勒比外蕊木、卓越希波克拉底木、波特川芎和长花薄荷毒性最大，半数致死量（LD50）值在1085至2毫克/千克之间。艾姆斯试验表明，鼠麴草属植物和高氏缬草提取物分别在有或无S9微粒体组分的情况下诱导鼠伤寒沙门氏菌TA98发生突变，在有酶组分存在的情况下诱导TA100发生突变。然而，高氏缬草酊剂无致突变性。最后，在卤虫致死试验中，紫茎泽兰叶千里光、托卢卡阿辣卡西亚、长花薄荷和圣胡椒导致甲壳类幼虫大量死亡，半数致死浓度（LC50）在37至227微克/毫升范围内。
