Lan Yu-Long, Wang Xun, Xing Jin-Shan, Lou Jia-Cheng, Ma Xiao-Chi, Zhang Bo
Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.
Department of Neurosurgery, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, 116033, People's Republic of China.
Acta Neurol Belg. 2017 Sep;117(3):613-621. doi: 10.1007/s13760-016-0730-2. Epub 2016 Dec 20.
Despite the numerous promising discoveries in contemporary cancer research and the emerging innovative cancer treatment strategies, the global burden of malignant glioma is expected to increase, partially due to its poor prognosis and human aging. Dopamine, a monoamine catecholamine neurotransmitter, is currently regarded as an important endogenous regulator of tumor growth. Dopamine may be an important treatment for brain tumors and could impact the pathogenesis of glioma by regulating tumor angiogenesis and vasculogenesis. Additionally, dopamine might exert an anti-glioma, cytotoxic effect by modulating apoptosis and autophagy. Dopamine and its receptors are also known to influence the immune system, as it is related to the pathogenesis of glioma. Dopamine may also increase the efficacy of anti-cancer drugs. Here, we review the potential roles of dopamine in malignant glioma and further identify the previously unknown function of dopamine as a potent regulator in the pathogenesis of glioma. Currently, the precise mechanisms regarding the protective effect of dopamine on glioma are poorly understood. However, our experimental results strongly emphasize the importance of this topic in future investigations.
尽管当代癌症研究中有众多前景广阔的发现以及新兴的创新癌症治疗策略，但恶性胶质瘤的全球负担预计仍将增加，部分原因是其预后较差以及人口老龄化。多巴胺作为一种单胺类儿茶酚胺神经递质，目前被视为肿瘤生长的重要内源性调节因子。多巴胺可能是脑肿瘤的一种重要治疗方法，并且可能通过调节肿瘤血管生成和血管发生来影响胶质瘤的发病机制。此外，多巴胺可能通过调节细胞凋亡和自噬发挥抗胶质瘤的细胞毒性作用。多巴胺及其受体也已知会影响免疫系统，因为这与胶质瘤的发病机制有关。多巴胺还可能提高抗癌药物的疗效。在此，我们综述了多巴胺在恶性胶质瘤中的潜在作用，并进一步确定了多巴胺作为胶质瘤发病机制中一种强效调节因子的此前未知的功能。目前，关于多巴胺对胶质瘤保护作用的确切机制尚不清楚。然而，我们的实验结果强烈强调了该主题在未来研究中的重要性。
