Phillips J I
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg.
S Afr Med J. 1989 Oct 7;76(7):355-7.
Biopsies were obtained from 47 children with upper respiratory tract infection aged 30 days - 12 years. All had been extensively investigated and no underlying cause for their symptoms could be found. A total of 63 specimens (46 from the inferior nasal turbinate, 8 from the trachea and 9 from the carina or bronchus) were examined. Only 4 showed no degree of squamous metaplasia and 8 showed significant numbers of acquired-type morphological abnormalities of the cilia. Twenty-six of the 63 biopsies had significantly reduced numbers of cilia and 34 had no cilia. Inherited-type changes were seen in only 1 patient. The net result of a lack of cilia and the immotile-cilia syndrome is the same--absence of mucociliary transport.
对47名年龄在30天至12岁的上呼吸道感染儿童进行了活检。所有患儿均经过广泛检查，未发现症状的潜在病因。共检查了63个标本（46个来自下鼻甲，8个来自气管，9个来自隆突或支气管）。只有4个标本未显示任何程度的鳞状化生，8个标本显示纤毛有大量获得性形态异常。63份活检标本中，26份纤毛数量显著减少，34份无纤毛。仅在1例患者中观察到遗传性改变。纤毛缺乏和纤毛不动综合征的最终结果是相同的——黏液纤毛运输缺失。
