Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54907, South Korea.
Deparment of Radiation oncology, Presbyterian Medical Center, Seonam University Medical School, Jeonju, Chonbuk 54987, South Korea.
Sci Data. 2016 Dec 20;3:160114. doi: 10.1038/sdata.2016.114.
The molecular mechanism underlying lifespan extension by resveratrol remains widely discussed. To help study this mechanism, we previously created resveratrol-enriched rice, DJ526, by transferring the resveratrol biosynthesis gene into Dongjin rice. DJ526 accumulates 1.4-1.9 μg g of resveratrol in its grain and can ameliorates age-related deterioration in mice, as compared to control animals, based on assessments of motor coordination, physical strength and cutaneous tissue aging. Here, we present raw data sets, deposited in public repositories, from microarray analysis and physiological data of mice fed with DJ526 and Dongjin rice and treated with resveratrol. We also provide a method to analyze blood serum at micron levels. These data sets may help other researchers find new clues regarding the etiology of the anti-aging process and signaling pathways induced by resveratrol, rice, or DJ526.
白藜芦醇延长寿命的分子机制仍在广泛讨论中。为了帮助研究这一机制，我们之前通过将白藜芦醇生物合成基因转入到冬金稻中，创造了富含白藜芦醇的水稻 DJ526。与对照动物相比，DJ526 其米粒中积累了 1.4-1.9μg/g 的白藜芦醇，可改善与年龄相关的小鼠恶化情况，其依据是对运动协调、体力和皮肤组织老化的评估。在这里，我们提供了来自微阵列分析和用 DJ526 和冬金稻喂养的小鼠以及用白藜芦醇处理的小鼠的生理数据的原始数据集，并已存入公共数据库中。我们还提供了一种分析血清中微物质的方法。这些数据集可能有助于其他研究人员发现与白藜芦醇、大米或 DJ526 诱导的抗衰老过程和信号通路相关的新线索。
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