Chung Hea-Jong, Sharma Satya Priya, Kim Hyeon-Jin, Baek So-Hyeon, Hong Seong-Tshool
Department of Biomedical Sciences and Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Chonbuk 54896, South Korea.
JINIS BDRD institute, JINIS Biopharmaceuticals Co., 948-9 Dunsan, Bongdong, Wanju, Chonbuk 55321, South Korea.
Sci Rep. 2016 Apr 5;6:23958. doi: 10.1038/srep23958.
The main objective of current genetic modifications in crops is to boost agricultural production or to develop GM crops with an improved nutrient profile by introducing a new trait to the plants. A GM crop surpassing the ability of the introduced genetic characteristics has not been developed yet. Here, we show that the resveratrol-enriched rice DJ526, a GM crop, has unexpectedly high beneficial health effects surpassing the introduced genetic characteristic of resveratrol synthetic ability. The synergistic effect of its innate and transgenic properties not only ameliorates age-related deterioration but also boosts motor coordination and physical strength during the aging process. The gene expression profiling analyses by DNA chip showed that the gene expression pattern of mice fed resveratrol-enriched rice DJ526 was very different from mice fed either resveratrol or Dongjin rice alone, respectively, modifying expression of genes related to aging regulation, cell differentiation, extracellular matrix, neurogenesis, or secretion.
当前对作物进行基因改造的主要目的是提高农业产量，或者通过给植物引入新特性来培育营养成分更佳的转基因作物。目前尚未培育出具有超越所导入遗传特性能力的转基因作物。在此，我们表明富含白藜芦醇的转基因水稻DJ526具有出人意料的高有益健康效果，超越了所导入的白藜芦醇合成能力这一遗传特性。其固有特性和转基因特性的协同效应不仅改善了与年龄相关的衰退，还增强了衰老过程中的运动协调性和体力。通过DNA芯片进行的基因表达谱分析表明，喂食富含白藜芦醇的水稻DJ526的小鼠的基因表达模式，与分别单独喂食白藜芦醇或东津水稻的小鼠的基因表达模式非常不同，改变了与衰老调控、细胞分化、细胞外基质、神经发生或分泌相关的基因表达。
