用富含白藜芦醇的大米DJ - 526治疗肥胖症。
Treatment of obesity with the resveratrol-enriched rice DJ-526.
作者信息
Baek So-Hyeon, Chung Hea-Jong, Lee Heui-Kwan, D'Souza Roshan, Jeon Youngju, Kim Hyeon-Jin, Kweon Soon-Jong, Hong Seong-Tshool
机构信息
1] National Institute of Crop Science, Rural Development Administration, Iksan, Chonbuk, Korea [2].
1] Department of Biomedical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk, Korea [2].
出版信息
Sci Rep. 2014 Jan 27;4:3879. doi: 10.1038/srep03879.
Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4 μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.
肥胖是世界上最普遍的疾病，它对各种慢性疾病构成严重风险。然而，目前尚无任何能减轻体重且不产生严重副作用的治疗药物。为了通过营养补充剂方法预防和/或治疗肥胖及相关疾病，我们培育出了一种富含白藜芦醇的转基因水稻DJ - 526，其谷粒中白藜芦醇的积累量为1.4微克/克。用富含白藜芦醇的水稻DJ - 526喂养小鼠，与对照组相比，体重和腹部脂肪量分别降低了20.0%和31.3%，显示出优异的抗肥胖效果。此外，在动物实验中，食用富含白藜芦醇的水稻DJ526能显著改善血脂谱和血糖水平。我们的富含白藜芦醇的水稻DJ - 526可为肥胖及相关疾病患者提供安全便捷的方式，无需改变主要生活方式，也不会产生药物带来的不良副作用。
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