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从食用昆虫短角幽天牛（科尔贝）中分离出的吲哚生物碱对血小板聚集和血栓形成的抑制作用。

Inhibition of platelet aggregation and thrombosis by indole alkaloids isolated from the edible insect Protaetia brevitarsis seulensis (Kolbe).

作者信息

Lee JungIn, Lee Wonhwa, Kim Mi-Ae, Hwang Jae Sam, Na MinKyun, Bae Jong-Sup

机构信息

College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.

College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu, Republic of Korea.

出版信息

J Cell Mol Med. 2017 Jun;21(6):1217-1227. doi: 10.1111/jcmm.13055. Epub 2016 Dec 20.

DOI:10.1111/jcmm.13055
PMID:27997749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5431138/
Abstract

Protaetia brevitarsis seulensis (Kolbe) has been temporarily registered as a food material by the Ministry of Food and Drug Safety of Korea (MFDS). The current study aimed to discover small antithrombotic molecules from this edible insect. Five indole alkaloids, 5-hydroxyindolin-2-one (1), (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (2), (1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (3), (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (4) and L-tryptophan (5), were isolated from the insect. Among them, compounds 1 and 2 prolonged aPTT and PT and impaired thrombin and FXa generation on HUVEC surface. Moreover, these compounds inhibited platelet aggregation. Antithrombotic effects of compounds 1 and 2 were further confirmed in pre-clinical models of pulmonary embolism and arterial thrombosis. Collectively, these results demonstrated that compounds 1 and 2 could be effective antithrombotic agents and serve as new scaffolds for the development of antithrombotic drug.

摘要

短角幽天牛已被韩国食品药品安全部（MFDS）临时登记为食品原料。本研究旨在从这种可食用昆虫中发现小的抗血栓分子。从该昆虫中分离出了5种吲哚生物碱，即5-羟基吲哚啉-2-酮（1）、（1R，3S）-1-甲基-1,2,3,4-四氢-β-咔啉-3-羧酸（2）、（1S，3S）-1-甲基-1,2,3,4-四氢-β-咔啉-3-羧酸（3）、（3S）-1,2,3,4-四氢-β-咔啉-3-羧酸（4）和L-色氨酸（5）。其中，化合物1和2延长了活化部分凝血活酶时间（aPTT）和凝血酶原时间（PT），并损害了人脐静脉内皮细胞（HUVEC）表面凝血酶和凝血因子Xa（FXa）的生成。此外，这些化合物还抑制血小板聚集。化合物1和2的抗血栓作用在肺栓塞和动脉血栓形成的临床前模型中得到了进一步证实。总的来说，这些结果表明化合物1和2可能是有效的抗血栓药物，并可作为开发抗血栓药物的新骨架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/6e343ca4c8d1/JCMM-21-1217-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/6ab27829e249/JCMM-21-1217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/9f02d3a3bf15/JCMM-21-1217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/dd02519caeb5/JCMM-21-1217-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/eb75aeda2a50/JCMM-21-1217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/6e343ca4c8d1/JCMM-21-1217-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/6ab27829e249/JCMM-21-1217-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/9f02d3a3bf15/JCMM-21-1217-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/dd02519caeb5/JCMM-21-1217-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/eb75aeda2a50/JCMM-21-1217-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e242/5431138/6e343ca4c8d1/JCMM-21-1217-g005.jpg

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2
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3
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Front Cardiovasc Med. 2024 Oct 11;11:1411306. doi: 10.3389/fcvm.2024.1411306. eCollection 2024.
4
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Microorganisms. 2024 Feb 29;12(3):496. doi: 10.3390/microorganisms12030496.
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