Pak Kang Yeun, Kim Sung Il, Lee Jong Soo
*Department of Ophthalmology, Haeundae Paik Hospital, Inje University, Busan, Korea; †Department of Ophthalmology, School of Medicine, Pusan National University, Busan, Korea; and ‡Medical Research Institute, Pusan National University Hospital, Busan, Korea.
Cornea. 2017 Apr;36(4):415-418. doi: 10.1097/ICO.0000000000001122.
To investigate the microbial cause and antibiotic susceptibility of neonatal bacterial conjunctivitis in Korean patients in the 21st century.
We retrospectively reviewed the medical records of patients diagnosed with neonatal bacterial conjunctivitis between January 2000 and December 2015. We recorded the organism, antibiotic susceptibility, and antibiotics used.
A total of 82 neonates were included in the study (53 males and 29 females), with a mean age of 17.5 ± 7.1 days. The most commonly isolated organisms were Staphylococcus aureus (43 cases, 52.4%), coagulase-negative staphylococci (11 cases, 13.4%), Staphylococcus epidermidis (11 cases, 13.4%), Serratia marcescens (4 cases, 4.9%), Pseudomonas aeruginosa (4 cases, 4.9%), and Enterobacter cloacae (3 cases, 3.7%). We found no cases of Neisseria gonorrhoeae or Chlamydia trachomatis infection. Resistance to methicillin (83.7%), macrolide (81.4%), and aminoglycoside (23.3%) was observed in patients with S. aureus infection. Conjunctivitis that did not improve with erythromycin or tobramycin generally improved with the additional use of tosufloxacin.
The prevalence of neonatal gonococcal or chlamydial conjunctivitis has decreased in the 21st century. However, methicillin-resistant S. aureus has been increasing, but these cases are responsive to tosufloxacin.
调查21世纪韩国新生儿细菌性结膜炎的微生物病因及抗生素敏感性。
我们回顾性分析了2000年1月至2015年12月期间诊断为新生儿细菌性结膜炎的患者的病历。我们记录了病原体、抗生素敏感性及使用的抗生素。
本研究共纳入82例新生儿（男53例，女29例），平均年龄17.5±7.1天。最常分离出的病原体为金黄色葡萄球菌（43例，52.4%）、凝固酶阴性葡萄球菌（11例，13.4%）、表皮葡萄球菌（11例，13.4%）、粘质沙雷氏菌（4例，4.9%）、铜绿假单胞菌（4例，4.9%）和阴沟肠杆菌（3例，3.7%）。我们未发现淋病奈瑟菌或沙眼衣原体感染病例。金黄色葡萄球菌感染患者对甲氧西林（83.7%）、大环内酯类（81.4%）和氨基糖苷类（23.3%）耐药。红霉素或妥布霉素治疗无效的结膜炎，加用妥舒沙星后通常会改善。
21世纪新生儿淋菌性或衣原体性结膜炎的患病率有所下降。然而，耐甲氧西林金黄色葡萄球菌一直在增加，但这些病例对妥舒沙星有反应。
