Hashish Aiman Abdeltawwab, Elbakary Molham Abdelhafez, Allam Waleed Abdelhady
J Pediatr Ophthalmol Strabismus. 2018 Mar 1;55(2):135-139. doi: 10.3928/01913913-20170718-01. Epub 2017 Nov 14.
To study the microbiological aspects of infantile bacterial conjunctivitis resistant to empirical topical antibiotic therapy in Egypt.
Ninety-two eyes of 86 infants with bacterial conjunctivitis were included in this prospective study. They all failed to show evidence of clinical improvement after 2 weeks of empirical topical antibiotic therapy. Conjunctival swabs were obtained from all patients for bacterial culture and antibiotic sensitivity testing.
The age of the participants ranged from 4 to 6 months. Culture results revealed infection with a solitary organism in 48.9% of eyes. Mixed bacterial growth was reported in 47.8% of eyes, whereas 3.3% of eyes showed no bacterial growth. The most commonly isolated organisms were Staphylococcus aureus, Streptococcus pneumoniae, and Pseudomonas aeruginosa. These organisms were highly sensitive to fluoroquinolones (levofloxacin, ciprofloxacin, ofloxacin, and norfloxacin), followed by chloramphenicol, vancomycin, and amikacin, and were resistant to carbapenems (imipenem and meropenem), fusidic acid, and pipracellin.
Bacterial culture and antibiotic sensitivity testing provides beneficial diagnostic and therapeutic information when dealing with infantile resistant bacterial conjunctivitis. [J Pediatr Ophthalmol Strabismus. 2018;55(2):135-139.].
研究埃及对经验性局部抗生素治疗耐药的婴儿细菌性结膜炎的微生物学特征。
本前瞻性研究纳入了86例患有细菌性结膜炎的婴儿的92只眼。他们在接受2周的经验性局部抗生素治疗后均未显示出临床改善的迹象。从所有患者中获取结膜拭子进行细菌培养和抗生素敏感性测试。
参与者的年龄在4至6个月之间。培养结果显示，48.9%的眼感染了单一微生物。47.8%的眼报告有混合细菌生长，而3.3%的眼未显示细菌生长。最常分离出的微生物是金黄色葡萄球菌、肺炎链球菌和铜绿假单胞菌。这些微生物对氟喹诺酮类药物（左氧氟沙星、环丙沙星、氧氟沙星和诺氟沙星）高度敏感，其次是氯霉素、万古霉素和阿米卡星，对碳青霉烯类药物（亚胺培南和美罗培南）、夫西地酸和哌拉西林耐药。
在处理婴儿耐药细菌性结膜炎时，细菌培养和抗生素敏感性测试可提供有益的诊断和治疗信息。[《小儿眼科与斜视杂志》。2018；55(2)：135 - 139。]
