From the *Section of Pediatric Dermatology, Children's Hospital of Philadelphia, PA; and †Department of Dermatology, University of Pennsylvania, Philadelphia.
Dermatitis. 2017 Jan/Feb;28(1):70-75. doi: 10.1097/DER.0000000000000256.
Allergic perineal dermatitis (PD) due to diaper wipes, topical medicaments, or diapers has been reported. Although patch testing is the criterion standard for detection of allergic contact dermatitis in children, this is limited by body surface area, decreased tolerance of the patch testing procedure, and increased false-positive rates due to irritant reactions. Therefore, a targeted patch testing series is necessary to better screen diapered infants for possible allergic PD.
We propose 2 patch test series (PD series 1 and 2) to screen infants with possible allergic PD.
Allergens are chosen using existing sensitization data of common allergens in children, published case reports, and the collective experience of American Contact Dermatitis Society members through an electronic survey.
PD series 1 includes 23 potential allergens found in wet wipes and topical diaper preparations. PD series 2 contains 10 potential allergens most commonly found in diapers.
We believe that these judiciously chosen patch test series will increase the yield of detecting the causes of allergic PD while not exposing children to an unnecessarily large screening patch test panel.
已报道过因尿布擦拭物、局部药物或尿布导致的过敏性会阴皮炎（PD）。虽然斑贴试验是儿童过敏性接触性皮炎检测的金标准，但由于儿童的体表面积有限、对斑贴试验过程的耐受性降低以及因刺激性反应导致的假阳性率增加，该方法受到限制。因此，有必要进行有针对性的斑贴试验系列检查，以便更好地筛查可能患有过敏性 PD 的尿布包裹婴儿。
我们提出了 2 个斑贴试验系列（PD 系列 1 和 2），以筛查可能患有过敏性 PD 的婴儿。
使用儿童常见过敏原的现有致敏数据、已发表的病例报告以及美国接触性皮炎学会成员通过电子调查的集体经验，选择过敏原。
PD 系列 1 包含在湿纸巾和局部尿布制剂中发现的 23 种潜在过敏原。PD 系列 2 包含在尿布中最常发现的 10 种潜在过敏原。
我们认为，这些经过精心挑选的斑贴试验系列将提高检测过敏性 PD 病因的效果，同时又不会使儿童接触到不必要的大型筛查斑贴试验组合。
