介孔硅纳米粒子包覆的石墨烯量子点用于潜在的化学-光热协同癌症治疗。
Mesoporous Silica Nanoparticles Capped with Graphene Quantum Dots for Potential Chemo-Photothermal Synergistic Cancer Therapy.
机构信息
School of Materials Science and Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Shanghai 200093, China.
Hubei Key Laboratory of Processing and Application of Catalytic Materials, College of Chemical Engineering, Huanggang Normal University , Huanggang 438000, China.
出版信息
Langmuir. 2017 Jan 17;33(2):591-599. doi: 10.1021/acs.langmuir.6b04189. Epub 2016 Dec 30.
In this study, mesoporous silica nanoparticles (MSNs) have been successfully capped with graphene quantum dots (GQDs) to form multifunctional GQD-MSNs with the potential for synergistic chemo-photothermal therapy. The structure, drug-release behavior, photothermal effect, and synergistic therapeutic efficiency of GQD-MSNs to 4T1 breast cancer cells were investigated. The results showed that GQD-MSNs were monodisperse and had a particle size of 50-60 nm. Using doxorubicin hydrochloride (DOX) as a model drug, the DOX-loaded GQD-MSNs (DOX-GQD-MSNs) not only exhibited pH- and temperature-responsive drug-release behavior, but using near-infrared irradiation, they efficiently generated heat to kill cancer cells. Furthermore, GQD-MSNs were biocompatible and were internalized by 4T1 cells. Compared with chemotherapy and photothermal therapy alone, DOX-GQD-MSNs were much more effective in killing the 4T1 cells owing to a synergistic chemo-photothermal effect. Therefore, GQD-MSNs may have promising applications in cancer therapy.
在这项研究中，成功地在介孔硅纳米粒子（MSNs）表面包覆了石墨烯量子点（GQDs），形成了具有协同化学-光热治疗潜力的多功能 GQD-MSNs。研究了 GQD-MSNs 对 4T1 乳腺癌细胞的结构、药物释放行为、光热效应和协同治疗效率。结果表明，GQD-MSNs 为单分散性的，粒径为 50-60nm。以盐酸阿霉素（DOX）为模型药物，载 DOX 的 GQD-MSNs（DOX-GQD-MSNs）不仅表现出 pH 和温度响应性的药物释放行为，而且在近红外辐射下，能够有效地产生热量杀死癌细胞。此外，GQD-MSNs 具有生物相容性，并被 4T1 细胞内化。与单独的化疗和光热治疗相比，由于协同的化学-光热效应，DOX-GQD-MSNs 对 4T1 细胞的杀伤效果要好得多。因此，GQD-MSNs 在癌症治疗中可能具有广阔的应用前景。
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