Mirazimi Seyed Mohammad Ali, Dashti Fatemeh, Tobeiha Mohammad, Shahini Ali, Jafari Raha, Khoddami Mehrad, Sheida Amir Hossein, EsnaAshari Parastoo, Aflatoonian Amir Hossein, Elikaii Fateme, Zakeri Melika Sadat, Hamblin Michael R, Aghajani Mohammad, Bavarsadkarimi Minoodokht, Mirzaei Hamed
School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Front Pharmacol. 2022 Apr 6;13:860209. doi: 10.3389/fphar.2022.860209. eCollection 2022.
Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).
许多细胞信号通路参与细胞增殖、分裂、运动及凋亡的调控。这些通路的失调会导致肿瘤细胞的起始和肿瘤进展。最近，天然产物作为一种有前景的癌症治疗策略受到了广泛关注。槲皮素是一种广泛存在于常见食物中的天然黄酮醇化合物。槲皮素通过多种作用机制对肿瘤进展显示出显著的抑制作用。这些机制包括诱导细胞周期停滞或/和凋亡以及其抗氧化特性。在此，我们总结了槲皮素在胃肠道癌症（胰腺癌、胃癌、结直肠癌、食管癌、肝细胞癌和口腔癌）中的治疗作用。
