Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Exp Cell Res. 2013 Jun 10;319(10):1357-64. doi: 10.1016/j.yexcr.2013.03.021. Epub 2013 Mar 25.
Apical-basal polarity is the basic organizing principle of epithelial cells, and endows epithelial cells to function as defensive barriers and as mediators of vectorial transport of nutrients in and out of organisms. Apical-basal polarity is controlled by a number of conserved polarity factors that regulate cytoskeletal organizations, asymmetric distributions of cellular components, and directional transports across cells. Polarity factors often occupy specific membrane regions in response to the adhesion forces generated by cell-cell and cell-extracellular matrix interactions. Both internal polarity factors and the external extracellular matrices play fundamental roles in epithelial cell polarity establishment and maintenance. This review focuses on recent developments of the Par3/Par6/aPKC complex and its interacting proteins in epithelial cell polarity.
顶端-基底极性是上皮细胞的基本组织原则，使上皮细胞能够作为防御屏障，并作为营养物质在生物体内外的载体运输的介质。顶端-基底极性由许多保守的极性因子控制，这些因子调节细胞骨架组织、细胞成分的不对称分布和细胞内的定向运输。极性因子通常在响应细胞-细胞和细胞-细胞外基质相互作用产生的粘附力时，占据特定的膜区域。内部极性因子和外部细胞外基质在建立和维持上皮细胞极性方面都起着至关重要的作用。本综述重点介绍了 Par3/Par6/aPKC 复合物及其在上皮细胞极性中的相互作用蛋白的最新进展。
