Oh Kyung-Hwan, Jung Su-Mi, Shin Eunkyung, Chung Gyung Tae, Seong Won-Keun, Cho Seung-Hak
Division of Enteric Diseases, Center for Infectious Diseases, Korea National Institute of Health.
Center for Infectious Diseases, Korea National Institute of Health.
Jpn J Infect Dis. 2017 May 24;70(3):320-322. doi: 10.7883/yoken.JJID.2016.178. Epub 2016 Dec 22.
We compared 47 enterohemorrhagic Escherichia coli (EHEC) O157 isolates with 184 EHEC non-O157 isolates from Korean patients with diarrhea. In the O157 group, the strains harboring both Shiga toxin genes (stx1 and stx2) were detected with highest frequency, whereas the strains harboring only stx1 gene were most frequently detected in the non-O157 group. Eight virulence genes (eaeA, hlyA, ehx, iha, efa1, tir, toxB, and espA) were found to show a higher frequency of occurrence in the O157 group than in the non-O157 group. In addition, the symptom of bloody diarrhea was exhibited at a higher rate in the O157 group (51.1%) than in the non-O157 group (16.8%). Our findings demonstrate that EHEC O157 strains are more frequently implicated in cases of bloody diarrhea in the Korean population than EHEC non-O157 strains.
我们将47株肠出血性大肠杆菌（EHEC）O157分离株与184株来自韩国腹泻患者的非O157 EHEC分离株进行了比较。在O157组中，同时携带志贺毒素基因（stx1和stx2）的菌株检出频率最高，而仅携带stx1基因的菌株在非O157组中检出频率最高。发现8个毒力基因（eaeA、hlyA、ehx、iha、efa1、tir、toxB和espA）在O157组中的出现频率高于非O157组。此外，O157组（51.1%）出现血性腹泻症状的比例高于非O157组（16.8%）。我们的研究结果表明，在韩国人群中，EHEC O157菌株比非O157 EHEC菌株更常引发血性腹泻病例。
