Chen Yue-Chan, Wei Hong, Zhang Zhi-Wei
Department of Basic Medicine, School of Medicine, Shihezi University, Shihezi 832000, China.
Office of Scientific Research, The First Affiliated Hospital of School of Medicine, Shihezi University, Shihezi 832000, China.
Sheng Li Xue Bao. 2016 Dec 25;68(6):809-815.
Krüppel-like factor 7 (KLF7), a member of Krüppel-like transcription factors (KLFs), also known as ubiquitous Krüppel- like factor (UKLF), is ubiquitously expressed in various tissues of adult human beings. Genetics reports showed that the genetic polymorphism of KLF7 is associated with obesity, type 2 diabetes, mental development in human beings; and KLF7 methylation is associated with the development of diffuse gastric cancer (gastric adenocarcinoma). In addition, some genomics reports suggested that KLF7 is one of the key transcription factors in the regulatory networks of serum markers change during the cardiovascular disease. The function studies showed that KLF7 is involved in the regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cells maintenance. This review summarizes the research progress of KLF7 in genetic characteristics, protein structure and gene function.
Krüppel样因子7（KLF7）是Krüppel样转录因子（KLFs）家族的成员之一，也被称为遍在Krüppel样因子（UKLF），在成年人类的各种组织中均有广泛表达。遗传学报告显示，KLF7的基因多态性与人类肥胖、2型糖尿病、智力发育相关；且KLF7甲基化与弥漫性胃癌（胃腺癌）的发生发展有关。此外，一些基因组学报告表明，KLF7是心血管疾病期间血清标志物变化调控网络中的关键转录因子之一。功能研究表明，KLF7参与神经系统和脂肪组织的发育与功能调控、2型糖尿病、血液疾病以及多能细胞的维持。本文综述了KLF7在遗传特征、蛋白质结构和基因功能方面的研究进展。
