Cole Emily D, Ferrara Daniela, Novais Eduardo A, Louzada Ricardo N, Waheed Nadia K
*New England Eye Center, Tufts Medical Center, Boston, Massachusetts; †Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts; ‡Federal University of Goiás, Goiânia, Brazil; and §School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Retina. 2016 Dec;36 Suppl 1:S83-S92. doi: 10.1097/IAE.0000000000001338.
To describe qualitative and quantitative optical coherence tomography (OCT) angiography (OCTA) parameters for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and their applicability as potential clinical trial endpoints.
A review of current literature related to the topic of OCTA and AMD.
There are a number of promising OCTA parameters that can be used to diagnose the presence of CNV and to monitor the activity and progression of the lesion, pre- and post-treatment morphological characteristics, CNV dimensions, and automated quantitative parameters such as vessel density.
The OCTA parameters described in this review have promise for the future development of clinical trial endpoints, but require further validation before they can be widely used.
描述年龄相关性黄斑变性（AMD）继发脉络膜新生血管（CNV）的定性和定量光学相干断层扫描血管造影（OCTA）参数，以及这些参数作为潜在临床试验终点的适用性。
对当前与OCTA和AMD主题相关的文献进行综述。
有许多有前景的OCTA参数可用于诊断CNV的存在、监测病变的活动和进展、治疗前后的形态特征、CNV尺寸以及诸如血管密度等自动定量参数。
本综述中描述的OCTA参数对临床试验终点的未来发展具有前景，但在广泛应用之前需要进一步验证。
