Damlar I, Arpağ O F, Tatli U, Altan A
Mustafa Kemal University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Hatay, Turkey.
Mustafa Kemal University, Faculty of Dentistry, Department of Periodontology, Hatay, Turkey.
Br J Oral Maxillofac Surg. 2017 May;55(4):383-387. doi: 10.1016/j.bjoms.2016.12.003. Epub 2016 Dec 20.
The aim of this study was to investigate effects of the Hypericum perforatum (St John's Wort) on bone healing in rabbit calvarium. Ten male New Zealand rabbits each had three bicortical defects made in the calvarial bones, which were filled with xenograft, xenograft+H perforatum oil extract, and autogenous graft. Four weeks postoperatively all rabbits were killed and the bony defects examined histomorphometrically. Tissue compartments including new bone (p<0.001), marrow space (p<0.001), and residual bone grafts (p=0.014) differed significantly among groups. The volume of residual graft was significantly decreased in the xenograft/H perforatum group compared with those with xenografts alone (p=0.0147). The differences in microarchitectural variables of de novo bone formation were also significant (trabecular thickness (p<0.001), trabecular width (p<0.001), trabecular separation (p=0.001). There were no significant differences in node:terminus ratio between the xenograft/H perforatum group and the other two groups. However, the difference in node:terminus ratio between the autogenous graft and xenograft group was significant (p=0.001) Oil extracts of H perforatum improved bony healing in defects filled with bovine-derived xenografts.
本研究旨在探讨贯叶连翘（圣约翰草）对兔颅骨骨愈合的影响。10只雄性新西兰兔，每只兔的颅骨制造3个双皮质缺损，缺损处分别填充异种移植物、异种移植物+贯叶连翘油提取物和自体移植物。术后4周处死所有兔子，对骨缺损进行组织形态计量学检查。各实验组之间的组织成分，包括新骨（p<0.001）、骨髓腔（p<0.001）和残余骨移植物（p=0.014）存在显著差异。与单纯异种移植物组相比，异种移植物/贯叶连翘组的残余移植物体积显著减少（p=0.0147）。新生骨形成的微观结构变量差异也很显著（骨小梁厚度（p<0.001）、骨小梁宽度（p<0.001）、骨小梁间距（p=0.001）。异种移植物/贯叶连翘组与其他两组之间的节点:末端比率无显著差异。然而，自体移植物组与异种移植物组之间的节点:末端比率差异显著（p=0.001）。贯叶连翘油提取物可促进填充牛源异种移植物的缺损部位的骨愈合。
