[Effect of the cerebrospinal fluid from patients with cerebral pathology on regional cerebral blood flow in experimental animals].

In 15 chronically instrumented rabbits the local cerebral blood flow was measured in frontal, parietal and temporal cerebral cortex while high-molecular weight (protein) and low-molecular weight (peptide) fractions of cerebrospinal fluid (CSF) of epileptic and subarachnoidal hemorrhage patients was infused into their lateral brain ventricles. High molecular-weight fraction elicited pronounced and long-lasting vasoactive effects. This fraction taken from epileptic patients increased and from subarachnoidal hemorrhage patients decreased the local cerebral blood flow. The low-molecular weight fraction caused brief local cerebral flow changes in rabbits: an increase when taken from epileptic patients and decrease with epileptic patients' fraction.