Kaboodkhani Reza, Karimi Ebrahim, Khorsandi Ashtiani Mohammad Taghi, Kowkabi Safoura, Firouzifar Mohammad Reza, Yazdani Farzad, Yazdani Nasrin
Department of Otorhinolaryngology and Head and Neck Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
Otorhinolaryngology Research Center, Tehran University of Medical Siences, Tehran, Iran.
Iran J Otorhinolaryngol. 2016 Nov;28(89):407-411.
90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis.
Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody.
There was no significant correlation between CD44 and survival (P=0.77), age (P=0.4), CD44 and lymph node metastasis (P=0.87), sex (P=0.947), smoking (P=0.287) and tumor size (P=0.813). However, there was significant correlation between smoking and survival.
There are widespread discrepancies among the findings in the literature regarding the prognosis of CD44 expression in OCSCC. Our study shows that the expression of CD44 is not a marker of aggressive behavior in oral tongue SCC. Consequently, CD44 cannot be considered as handy tool to establish the tumor behavior, prognosis and 5- year survival rate of these tumors.
头颈部90%的肿瘤为鳞状细胞癌（HNSCC），其总体5年生存率在50%至60%之间。已证明CD44与预后相关。
采用免疫组织化学（IHC）方法对51例口腔舌鳞状细胞癌患者的活检标本进行CD44抗体评估。
CD44与生存率（P = 0.77）、年龄（P = 0.4）、CD44与淋巴结转移（P = 0.87）、性别（P = 0.947）、吸烟（P = 0.287）及肿瘤大小（P = 0.813）之间均无显著相关性。然而，吸烟与生存率之间存在显著相关性。
关于口腔鳞状细胞癌中CD44表达的预后，文献中的研究结果存在广泛差异。我们的研究表明，CD44的表达并非口腔舌鳞状细胞癌侵袭性行为的标志物。因此，CD44不能被视为确定这些肿瘤的行为、预后及5年生存率的便捷工具。
