Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Faculty of Medicine, The University of Queensland, St Lucia, Queensland, Australia.
Clin Transplant. 2022 Dec;36(12):e14819. doi: 10.1111/ctr.14819. Epub 2022 Sep 25.
Long-term changes in weight and blood lipids beyond 12 months after heart transplantation are largely unknown. We quantified changes in weight, body mass index (BMI), blood cholesterol, and triglycerides in heart transplant recipients (HTRs) during the 36 months after transplantation, and we assessed the influence of statin therapy on these outcomes.
Retrospective cohort study of adult HTRs, transplanted 1990-2017, in Queensland, Australia. From each patient's medical charts, we extracted weight, total cholesterol, triglycerides, and statin therapy at four time-points: time of transplant (baseline), and 12-, 24-, 36-month post-transplant. Changes in weight and blood lipids were assessed according to baseline BMI.
Among 316 HTRs, 236 (median age 52 years, 83% males) with available information were included. During the 36 months post-transplant, all patients gained weight (83.5-90.5 kg; p < .001), especially those with baseline BMI < 25.0 km/m (67.9-76.2 kg; p < .001). Mean blood cholesterol (4.60-4.90 mmol/L; p = .004) and mean blood triglycerides (1.79-2.18 mmol/L; p = .006) also increased significantly in all patients, particularly in those with baseline BMI ≥ 25.0 km/m but the differences were not significant (total cholesterol 4.42-5.13 mmol/L; triglycerides 1.76-2.47 mmol/L). Total cholesterol was highest in patients not taking statins, and levels differed significantly (p = .010) according to statin dosing changes during the 36 months post-transplant.
Patients demonstrate significant rises in weight and blood lipids in the 36 months after heart transplantation.
心脏移植后 12 个月以上的体重和血脂的长期变化尚不清楚。我们定量评估了 1990 年至 2017 年间在澳大利亚昆士兰州接受心脏移植的成年患者（HTRs）在移植后 36 个月期间的体重、体重指数（BMI）、胆固醇和甘油三酯的变化，并评估了他汀类药物治疗对这些结果的影响。
这是一项对 1990 年至 2017 年间在澳大利亚昆士兰州接受心脏移植的成年 HTRs 的回顾性队列研究。我们从每位患者的病历中提取了移植时（基线）以及移植后 12、24 和 36 个月时的体重、总胆固醇、甘油三酯和他汀类药物治疗情况。根据基线 BMI 评估体重和血脂的变化。
在 316 名 HTRs 中，有 236 名（中位年龄 52 岁，83%为男性）患者的信息可用。在移植后 36 个月期间，所有患者的体重均增加（83.5-90.5kg；p<0.001），尤其是基线 BMI<25.0kg/m2的患者（67.9-76.2kg；p<0.001）。所有患者的血液胆固醇（4.60-4.90mmol/L；p=0.004）和血液甘油三酯（1.79-2.18mmol/L；p=0.006）也显著升高，基线 BMI≥25.0kg/m2的患者尤其如此，但差异无统计学意义（总胆固醇 4.42-5.13mmol/L；甘油三酯 1.76-2.47mmol/L）。未服用他汀类药物的患者总胆固醇水平最高，且根据移植后 36 个月期间他汀类药物剂量的变化，其水平差异有统计学意义（p=0.010）。
心脏移植后 36 个月患者的体重和血脂明显升高。
