Venhuis B J, Zomer G, de Kaste D
National Institute for Public Health and the Environment, Postbox 1, 3720 BA, Bilthoven, The Netherlands.
J Pharm Biomed Anal. 2008 Mar 13;46(4):814-7. doi: 10.1016/j.jpba.2007.12.007. Epub 2007 Dec 15.
A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC-MS, UV and IR spectroscopy, MS-MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the CO moiety has been converted into a CS group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil.
在一种草本壮阳药中检测到了一种新的西地那非类似物。该化合物的结构通过液相色谱 - 质谱联用（LC-MS）、紫外（UV）和红外（IR）光谱、串联质谱（MS-MS）以及核磁共振（NMR）得以确定。这种名为硫代高西地那非的化合物是西地那非的一种合成N - 乙基哌嗪类似物，其中羰基（CO）部分也已转化为硫羰基（CS）基团。这是首次将在发色团处修饰的西地那非类似物鉴定为草本壮阳药的 adulterant。初步药理分析证实了硫代高西地那非的勃起功效。 （注：原文中“adulterant”未给出合适中文释义，可能是指“掺假成分”之类的意思，这里保留英文以便理解原文确切含义）
