Scarisoreanu N D, Craciun F, Ion V, Birjega R, Bercea A, Dinca V, Dinescu M, Sima L E, Icriverzi M, Roseanu A, Gruionu L, Gruionu G
National Institute for Laser, Plasma and Radiation Physics , 077125 Magurele, Romania.
CNR-ISC, Istituto dei Sistemi Complessi , Area della Ricerca di Roma-Tor Vergata, Via del Fosso del Cavaliere 100, I-00133 Rome, Italy.
ACS Appl Mater Interfaces. 2017 Jan 11;9(1):266-278. doi: 10.1021/acsami.6b14774. Epub 2016 Dec 23.
In this work, we report the synthesis of functional biocompatible piezoelectric (1 - x)Ba(TiZr)TiO-x(BaCa)TiO, x = 0.45 (BCZT45), thin films with high piezoelectric properties. Pulsed-laser-based techniques, classical pulsed-laser deposition and matrix-assisted pulsed-laser evaporation, were used to synthesize the BCZT45 thin films. The second technique was employed in order to ensure growth on polymer flexible Kapton substrates. The BCZT45 thin films grown by both techniques show similar structural properties and high piezoelectric coefficient coupling between the mechanical loading and electrical potential. While it has long been shown that the electrical potential favors biological processes like osteogenesis, the assessment of cell adhesion and osteogenic differentiation onto BCZT materials has not yet been demonstrated. We prove here for the first time that BCZT 45 coatings on Kapton polymer substrates provide optimal support for osteogenic differentiation of mesenchymal stem cells in the bone marrow.
在这项工作中，我们报道了具有高压电性能的功能性生物相容性压电(1 - x)Ba(TiZr)TiO-x(BaCa)TiO（x = 0.45，即BCZT45）薄膜的合成。基于脉冲激光的技术，即经典脉冲激光沉积和基质辅助脉冲激光蒸发，被用于合成BCZT45薄膜。采用第二种技术是为了确保在聚合物柔性聚酰亚胺（Kapton）衬底上生长。通过这两种技术生长的BCZT45薄膜显示出相似的结构特性以及机械载荷与电势之间的高压电系数耦合。虽然长期以来已经表明电势有利于诸如骨生成等生物过程，但尚未证明对BCZT材料上细胞粘附和成骨分化的评估。我们在此首次证明，Kapton聚合物衬底上的BCZT45涂层为骨髓间充质干细胞的成骨分化提供了最佳支持。
