Tariq Saba, Baig Mukhtiar, Tariq Sundus, Shahzad Muhammad
a Department of Pharmacology , University Medical and Dental College , Faisalabad , Pakistan.
b Department of Pharmacology , University of Health Sciences , Lahore , Pakistan.
Gynecol Endocrinol. 2017 Apr;33(4):287-291. doi: 10.1080/09513590.2016.1261103. Epub 2016 Dec 23.
Present study was designed to find out whether leptin is a predictor of bone mass density (BMD) in premenopausal women (PMW) and postmenopausal osteoporotic women (PMOPW) or it has no association with BMD.
One hundred and ninety two women (98 PMOPW and 94 PMW) were recruited for this study. The control group was BMI matched with osteoporotic subjects. BMD assessment was done on calcaneus by peripheral ultrasound bone densitometry and T scores were determined. Serum leptin levels were measured by enzyme-linked immunosorbent assay (ELISA).
Serum leptin and BMD values were significantly different in both groups (leptin, 18.56 ± 8.65 ng/ml versus 21.64 ± 9.80 ng/ml, p = 0.02) and (BMD, -0.70 ± 0.19 versus -3.17 ± 0.59, p = 0.000), respectively. In PMOPW serum leptin and BMD were considerably correlated with weight (lep, r = 0.53, p = <0.001; BMD, r = -0.21, p = 0.02), BMI (lep, r = 0.52, p = <0.001; BMD, r = -0.27, p = 0.005), waist circumference (lep, r = 0.61, p = <0.001; BMD, r = 0.18, p = 0.04), hip circumference (lep, r = 0.58, p = <0.001). Multivariate linear stepwise regression analysis showed that weight and BMI in PMW and PMOPW were independent predictors of BMD. Serum leptin level was not found to be the predictor of BMD in both groups.
The present results indicate that body weight and BMI have an impact on BMD while serum leptin is not associated with BMD in PMW and PMOPW.
本研究旨在探究瘦素是否为绝经前女性（PMW）和绝经后骨质疏松女性（PMOPW）骨密度（BMD）的预测指标，或者其与骨密度是否无关。
本研究招募了192名女性（98名PMOPW和94名PMW）。对照组的体重指数与骨质疏松受试者相匹配。通过外周超声骨密度测定法对跟骨进行骨密度评估，并确定T值。采用酶联免疫吸附测定法（ELISA）测量血清瘦素水平。
两组的血清瘦素和骨密度值均存在显著差异（瘦素，18.56±8.65 ng/ml对21.64±9.80 ng/ml，p = 0.02）以及（骨密度，-0.70±0.1玖-3.17±氏59，p = 0.000）。在PMOPW中，血清瘦素和骨密度与体重（瘦素，r = 0.53，p = <0.001；骨密度，r = -0.21，p = 0.02）、体重指数（瘦素，r = 0.52，p = <0.001；骨密度，r = -0.27，p = 0.005）、腰围（瘦素，r = 0.61，p = <0.001；骨密度，r = 0.18，p = 0.04）、臀围（瘦素，r = 0.58，p = <0.001）显著相关。多因素线性逐步回归分析表明，PMW和PMOPW中的体重和体重指数是骨密度的独立预测指标。在两组中均未发现血清瘦素水平是骨密度的预测指标。
目前结果表明，体重和体重指数对骨密度有影响，而在PMW和PMOPW中血清瘦素与骨密度无关。
