绝经后女性血清chemerin与钙、碱性磷酸酶及骨密度的相关性
Association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal females.
作者信息
Tariq Saba, Tariq Sundus, Shahzad Muhammad
机构信息
Saba Tariq, MBBS, M.Phil. Associate Professor, Pharmacology, University Medical & Dental College, Faisalabad-38000, Pakistan. PhD Research Scholar, Pharmacology, University of Health Sciences, Lahore, Pakistan.
Sundus Tariq, MBBS, M.Phil. Associate Professor, Physiology, University Medical & Dental College, Faisalabad-38000, Pakistan. PhD Research Scholar, Physiology, University of Health Sciences, Lahore, Pakistan.
出版信息
Pak J Med Sci. 2021 Mar-Apr;37(2):384-388. doi: 10.12669/pjms.37.2.3907.
OBJECTIVES
To investigate the association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal non-osteoporotic and osteoporotic females.
METHODS
This cross-section analysis was carried out at the orthopedic department of Madina Teaching Hospital, Faisalabad, Pakistan, in the year 2017-2019. Postmenopausal females were divided into two groups according to their bone mineral density (BMD). All osteoporotic females had a T-score of -2.5 or less. Data were analyzed on SPSS-24.
RESULTS
A total of 140 women were included in our study (80 osteoporotic and 60 non-osteoporotic). Non significant difference in age and BMI was observed between osteoporotic and non-osteoporotic subjects (p=0.152) and (p=0.291) respectively. There was a significant difference found in total BMD, serum chemerin levels between osteoporotic and non-osteoporotic subjects p<0.001 in both parameters. No significant correlation of serum chemerin was found with serum calcium, serum alkaline phosphatase and BMD in postmenopausal osteoporotic females (p=0.907), (p=0.318) (p=0.664) respectively. A significant negative correlation was found between serum alkaline phosphatase levels and total BMD in postmenopausal osteoporotic females (p=- 0.039). Linear regression analysis of serum alkaline phosphatase levels with total BMD showed no association between BMD and serum alkaline phosphatase levels (p=0.869).
CONCLUSION
There is no association of serum chemerin with calcium, ALP and bone mineral density in non-osteoporotic and osteoporotic postmenopausal females.
目的
探讨绝经后非骨质疏松和骨质疏松女性血清chemerin与钙、碱性磷酸酶及骨密度的关系。
方法
本横断面分析于2017 - 2019年在巴基斯坦费萨拉巴德麦地那教学医院骨科进行。绝经后女性根据骨密度（BMD）分为两组。所有骨质疏松女性的T值均为-2.5或更低。数据在SPSS - 24软件上进行分析。
结果
本研究共纳入140名女性（80名骨质疏松患者和60名非骨质疏松患者）。骨质疏松组和非骨质疏松组在年龄和体重指数方面无显著差异，分别为（p = 0.152）和（p = 0.291）。骨质疏松组和非骨质疏松组在总骨密度、血清chemerin水平方面存在显著差异，两个参数的p值均<0.001。绝经后骨质疏松女性血清chemerin与血清钙、血清碱性磷酸酶及骨密度之间未发现显著相关性，分别为（p = 0.907）、（p = 0.318）、（p = 0.664）。绝经后骨质疏松女性血清碱性磷酸酶水平与总骨密度之间存在显著负相关（p = -0.039）。血清碱性磷酸酶水平与总骨密度的线性回归分析显示骨密度与血清碱性磷酸酶水平之间无关联（p = 0.869）。
结论
绝经后非骨质疏松和骨质疏松女性血清chemerin与钙、碱性磷酸酶及骨密度之间无关联。
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