Xu G X, Xie X H
Yao Xue Xue Bao. 1989;24(2):133-8.
In this paper, a method--improved emulsification vesicles (IEV) was proposed for the preparation of adenosine triphosphate (ATP) liposome. The ATP entrapment ratio reached 38.9% (w/w), which was much greater than that reported in the literature. Thus, IEV is an excellent method which has never been presented. Together with ultrafiltration for removing unentrapped drugs and radiation sterilization, these methods are most meaningful for the production of liposomes in large scale.
本文提出了一种制备三磷酸腺苷（ATP）脂质体的方法——改进乳化囊泡法（IEV）。ATP包封率达到38.9%（w/w），远高于文献报道的值。因此，IEV是一种从未有过报道的优良方法。结合超滤去除未包封的药物和辐射灭菌，这些方法对大规模生产脂质体极具意义。
